MIR6511B1

Summary

MIR6511B1 (microRNA 6511b-1, HGNC:50228) is a microRNA gene on chromosome 16p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465429 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50228
Approved symbol	MIR6511B1
Name	microRNA 6511b-1
Location	16p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6511b-1
Ensembl gene	ENSG00000284008
Ensembl biotype	miRNA
Entrez	102465429
RNAcentral	URS000075D50D — miRNA, 85 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612014

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612014 — 1 exons

Exon	Start	End
ENSE00003712095	2106669	2106753

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 87.97.

Top tissues by expression

46 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	87.97	gold quality
calcaneal tendon	UBERON:0003701	79.99	gold quality
Ammon’s horn	UBERON:0001954	77.55	gold quality
blood	UBERON:0000178	75.18	gold quality
heart left ventricle	UBERON:0002084	74.97	gold quality
body of stomach	UBERON:0001161	72.61	gold quality
monocyte	CL:0000576	72.50	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.23	gold quality
body of uterus	UBERON:0009853	70.86	gold quality
amygdala	UBERON:0001876	70.08	gold quality
endometrium	UBERON:0001295	69.21	gold quality
ascending aorta	UBERON:0001496	69.12	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.01	gold quality
gastrocnemius	UBERON:0001388	67.72	gold quality
thoracic aorta	UBERON:0001515	67.56	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.33	gold quality
right frontal lobe	UBERON:0002810	67.17	gold quality
tibial nerve	UBERON:0001323	66.96	gold quality
left coronary artery	UBERON:0001626	66.30	gold quality
descending thoracic aorta	UBERON:0002345	66.19	gold quality
tibial artery	UBERON:0007610	65.50	gold quality
right atrium auricular region	UBERON:0006631	65.25	gold quality
left ovary	UBERON:0002119	64.96	gold quality
putamen	UBERON:0001874	64.93	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.44	gold quality
left adrenal gland cortex	UBERON:0035825	64.35	gold quality
vagina	UBERON:0000996	63.94	gold quality
nucleus accumbens	UBERON:0001882	63.33	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.28	gold quality
omental fat pad	UBERON:0010414	63.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MiR-6511b-5p suppresses metastasis of pMMR colorectal cancer through methylation of CD44 by directly targeting BRG1. (PMID:35590122)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.