MIR6512

Summary

MIR6512 (microRNA 6512, HGNC:50259) is a microRNA gene on chromosome 2q31.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465255 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50259
Approved symbol	MIR6512
Name	microRNA 6512
Location	2q31.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6512
Ensembl gene	ENSG00000278418
Ensembl biotype	miRNA
Entrez	102465255
RNAcentral	URS000075CCCD — miRNA, 77 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000615246

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000615246 — 1 exons

Exon	Start	End
ENSE00003712236	177313806	177313882

Expression profiles

Bgee: expression breadth ubiquitous, 103 present calls, max score 92.60.

Top tissues by expression

103 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	92.60	gold quality
duodenum	UBERON:0002114	83.81	gold quality
vermiform appendix	UBERON:0001154	82.15	gold quality
adrenal tissue	UBERON:0018303	81.40	gold quality
corpus callosum	UBERON:0002336	81.32	gold quality
bone marrow	UBERON:0002371	80.89	gold quality
calcaneal tendon	UBERON:0003701	78.52	gold quality
monocyte	CL:0000576	76.97	gold quality
adult mammalian kidney	UBERON:0000082	75.85	gold quality
endometrium	UBERON:0001295	75.37	gold quality
right adrenal gland cortex	UBERON:0035827	74.98	gold quality
smooth muscle tissue	UBERON:0001135	74.93	gold quality
kidney	UBERON:0002113	74.65	gold quality
blood	UBERON:0000178	74.50	gold quality
liver	UBERON:0002107	74.40	gold quality
right adrenal gland	UBERON:0001233	73.58	gold quality
muscle of leg	UBERON:0001383	73.27	gold quality
right lobe of liver	UBERON:0001114	72.65	gold quality
islet of Langerhans	UBERON:0000006	72.48	gold quality
granulocyte	CL:0000094	72.41	gold quality
placenta	UBERON:0001987	72.35	gold quality
gastrocnemius	UBERON:0001388	72.23	gold quality
heart left ventricle	UBERON:0002084	71.62	gold quality
lymph node	UBERON:0000029	71.27	gold quality
adrenal gland	UBERON:0002369	71.13	gold quality
gall bladder	UBERON:0002110	70.84	gold quality
heart	UBERON:0000948	70.74	gold quality
right coronary artery	UBERON:0001625	70.69	gold quality
left adrenal gland cortex	UBERON:0035825	69.72	gold quality
body of pancreas	UBERON:0001150	69.57	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.36

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• SNHG7 promotes the osteo/dentinogenic differentiation ability of human dental pulp stem cells by interacting with hsa-miR-6512-3p in an inflammatory microenvironment. (PMID:34653678)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.