MIR6513

Summary

MIR6513 (microRNA 6513, HGNC:50247) is a microRNA gene on chromosome 2q35.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465256 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50247
Approved symbol	MIR6513
Name	microRNA 6513
Location	2q35
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6513
Ensembl gene	ENSG00000284173
Ensembl biotype	miRNA
Entrez	102465256
RNAcentral	URS000075CFDD — miRNA, 64 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000621188

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000621188 — 1 exons

Exon	Start	End
ENSE00003738454	218280125	218280188

Expression profiles

Bgee: expression breadth broad, 29 present calls, max score 80.28.

Top tissues by expression

29 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right frontal lobe	UBERON:0002810	80.28	gold quality
gastrocnemius	UBERON:0001388	76.59	gold quality
lung	UBERON:0002048	73.53	gold quality
heart left ventricle	UBERON:0002084	73.12	gold quality
right atrium auricular region	UBERON:0006631	70.41	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.37	gold quality
blood	UBERON:0000178	64.93	gold quality
left adrenal gland cortex	UBERON:0035825	64.46	gold quality
tibial artery	UBERON:0007610	63.56	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.04	gold quality
body of pancreas	UBERON:0001150	61.04	gold quality
skin of abdomen	UBERON:0001416	60.91	gold quality
stomach	UBERON:0000945	60.33	gold quality
left adrenal gland	UBERON:0001234	60.17	gold quality
right lobe of thyroid gland	UBERON:0001119	59.59	gold quality
thoracic mammary gland	UBERON:0005200	59.21	gold quality
colon	UBERON:0001155	58.60	gold quality
minor salivary gland	UBERON:0001830	58.25	gold quality
skin of leg	UBERON:0001511	56.70	gold quality
subcutaneous adipose tissue	UBERON:0002190	56.58	gold quality
transverse colon	UBERON:0001157	56.27	gold quality
hypothalamus	UBERON:0001898	56.10	gold quality
tibial nerve	UBERON:0001323	55.35	gold quality
omental fat pad	UBERON:0010414	52.61	gold quality
thyroid gland	UBERON:0002046	50.71	gold quality
esophagus mucosa	UBERON:0002469	49.33	gold quality
small intestine Peyer’s patch	UBERON:0003454	49.07	gold quality
left lobe of thyroid gland	UBERON:0001120	48.50	gold quality
anterior cingulate cortex	UBERON:0009835	46.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.