MIR6514

Summary

MIR6514 (microRNA 6514, HGNC:50147) is a microRNA gene on chromosome 11q12.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465257 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50147
Approved symbol	MIR6514
Name	microRNA 6514
Location	11q12.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6514
Ensembl gene	ENSG00000274066
Ensembl biotype	miRNA
Entrez	102465257
RNAcentral	URS000075BA81 — ncRNA, 70 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622549

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622549 — 1 exons

Exon	Start	End
ENSE00003741997	62792702	62792771

Expression profiles

Bgee: expression breadth ubiquitous, 104 present calls, max score 93.29.

Top tissues by expression

104 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	93.29	gold quality
skeletal muscle tissue	UBERON:0001134	91.40	gold quality
placenta	UBERON:0001987	88.58	gold quality
vermiform appendix	UBERON:0001154	86.92	gold quality
bone marrow	UBERON:0002371	86.84	gold quality
duodenum	UBERON:0002114	85.11	gold quality
lymph node	UBERON:0000029	81.33	gold quality
blood	UBERON:0000178	81.33	gold quality
monocyte	CL:0000576	79.58	gold quality
adrenal tissue	UBERON:0018303	79.21	gold quality
calcaneal tendon	UBERON:0003701	76.74	gold quality
muscle of leg	UBERON:0001383	75.25	gold quality
endometrium	UBERON:0001295	75.04	gold quality
skin of abdomen	UBERON:0001416	74.86	gold quality
heart left ventricle	UBERON:0002084	73.93	gold quality
gastrocnemius	UBERON:0001388	73.84	gold quality
smooth muscle tissue	UBERON:0001135	73.56	gold quality
left adrenal gland cortex	UBERON:0035825	72.67	gold quality
heart	UBERON:0000948	72.66	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	72.58	gold quality
stomach	UBERON:0000945	72.53	gold quality
right lobe of liver	UBERON:0001114	72.52	gold quality
gall bladder	UBERON:0002110	72.50	gold quality
zone of skin	UBERON:0000014	72.47	gold quality
right coronary artery	UBERON:0001625	72.39	gold quality
adenohypophysis	UBERON:0002196	72.37	gold quality
islet of Langerhans	UBERON:0000006	72.35	gold quality
kidney	UBERON:0002113	72.29	gold quality
body of stomach	UBERON:0001161	72.12	gold quality
cerebellar hemisphere	UBERON:0002245	72.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.75

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.