MIR6515

Summary

MIR6515 (microRNA 6515, HGNC:50227) is a microRNA gene on chromosome 19p13.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466659 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50227
Approved symbol	MIR6515
Name	microRNA 6515
Location	19p13.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6515
Ensembl gene	ENSG00000274417
Ensembl biotype	miRNA
Entrez	102466659
RNAcentral	URS000075CDB4 — ncRNA, 57 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619843

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619843 — 1 exons

Exon	Start	End
ENSE00003729231	12940484	12940540

Expression profiles

Bgee: expression breadth broad, 72 present calls, max score 81.32.

Top tissues by expression

72 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	81.32	gold quality
bone marrow	UBERON:0002371	81.15	gold quality
monocyte	CL:0000576	79.85	gold quality
lymph node	UBERON:0000029	79.07	gold quality
muscle of leg	UBERON:0001383	77.92	gold quality
blood	UBERON:0000178	76.64	gold quality
gastrocnemius	UBERON:0001388	76.46	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	75.55	gold quality
skin of abdomen	UBERON:0001416	75.04	gold quality
calcaneal tendon	UBERON:0003701	75.03	gold quality
granulocyte	CL:0000094	73.96	gold quality
islet of Langerhans	UBERON:0000006	73.74	gold quality
kidney	UBERON:0002113	73.50	gold quality
left coronary artery	UBERON:0001626	71.96	gold quality
heart	UBERON:0000948	71.80	gold quality
right lobe of liver	UBERON:0001114	71.56	gold quality
heart left ventricle	UBERON:0002084	71.16	gold quality
stomach	UBERON:0000945	70.51	gold quality
liver	UBERON:0002107	70.48	gold quality
right atrium auricular region	UBERON:0006631	69.73	gold quality
body of stomach	UBERON:0001161	69.70	gold quality
adult mammalian kidney	UBERON:0000082	69.45	gold quality
omental fat pad	UBERON:0010414	69.14	gold quality
Ammon’s horn	UBERON:0001954	69.01	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.01	gold quality
adipose tissue	UBERON:0001013	68.98	gold quality
gall bladder	UBERON:0002110	68.93	gold quality
skin of leg	UBERON:0001511	68.78	gold quality
ascending aorta	UBERON:0001496	68.33	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The miRNA hsa-miR-6515-3p potentially contributes to lncRNA H19-mediated-lung cancer metastasis. (PMID:31131469)
• miRNA-6515-5p regulates particulate matter-induced inflammatory responses by targeting CSF3 in human bronchial epithelial cells. (PMID:35798096)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.