MIR6516

Summary

MIR6516 (microRNA 6516, HGNC:50233) is a microRNA gene on chromosome 17q25.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466864 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50233
Approved symbol	MIR6516
Name	microRNA 6516
Location	17q25.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6516
Ensembl gene	ENSG00000284250
Ensembl biotype	miRNA
Entrez	102466864
RNAcentral	URS000075C42D — ncRNA, 81 nt, 13 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000630554

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000630554 — 1 exons

Exon	Start	End
ENSE00003771350	77089417	77089497

Expression profiles

Bgee: expression breadth broad, 30 present calls, max score 95.66.

Top tissues by expression

30 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	95.66	gold quality
hypothalamus	UBERON:0001898	72.65	gold quality
liver	UBERON:0002107	66.83	silver quality
blood	UBERON:0000178	66.17	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.44	gold quality
islet of Langerhans	UBERON:0000006	64.77	gold quality
right atrium auricular region	UBERON:0006631	64.19	gold quality
lung	UBERON:0002048	63.64	gold quality
caudate nucleus	UBERON:0001873	61.38	gold quality
body of pancreas	UBERON:0001150	60.71	gold quality
transverse colon	UBERON:0001157	59.58	gold quality
ascending aorta	UBERON:0001496	58.82	gold quality
substantia nigra	UBERON:0002038	58.28	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	57.85	gold quality
omental fat pad	UBERON:0010414	57.61	gold quality
amygdala	UBERON:0001876	57.39	gold quality
gastrocnemius	UBERON:0001388	55.79	gold quality
nucleus accumbens	UBERON:0001882	55.73	gold quality
left adrenal gland	UBERON:0001234	54.71	gold quality
tibial artery	UBERON:0007610	54.59	gold quality
Ammon’s horn	UBERON:0001954	53.14	gold quality
fundus of stomach	UBERON:0001160	49.90	gold quality
right hemisphere of cerebellum	UBERON:0014890	49.07	gold quality
Brodmann (1909) area 9	UBERON:0013540	47.46	silver quality
subcutaneous adipose tissue	UBERON:0002190	47.45	silver quality
skin of abdomen	UBERON:0001416	46.12	silver quality
anterior cingulate cortex	UBERON:0009835	42.78	gold quality
left coronary artery	UBERON:0001626	41.76	gold quality
skin of leg	UBERON:0001511	39.26	silver quality
left testis	UBERON:0004533	32.88	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.