MIR652

Summary

MIR652 (microRNA 652, HGNC:32908) is a microRNA gene on chromosome Xq23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 724022 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32908
Approved symbol	MIR652
Name	microRNA 652
Location	Xq23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-652
Ensembl gene	ENSG00000208013
Ensembl biotype	miRNA
Entrez	724022
RNAcentral	URS000063C71D — miRNA, 98 nt, 10 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385278

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385278 — 1 exons

Exon	Start	End
ENSE00001500284	110055329	110055426

Expression profiles

Bgee: expression breadth broad, 26 present calls, max score 83.03.

Top tissues by expression

26 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	83.03	gold quality
adrenal tissue	UBERON:0018303	79.28	gold quality
stomach	UBERON:0000945	73.67	gold quality
heart	UBERON:0000948	72.62	gold quality
ascending aorta	UBERON:0001496	70.94	gold quality
tibial nerve	UBERON:0001323	67.49	gold quality
heart left ventricle	UBERON:0002084	67.37	gold quality
thoracic mammary gland	UBERON:0005200	66.97	gold quality
left lobe of thyroid gland	UBERON:0001120	66.75	gold quality
intestine	UBERON:0000160	66.63	gold quality
lung	UBERON:0002048	66.05	gold quality
caudate nucleus	UBERON:0001873	65.49	gold quality
skin of abdomen	UBERON:0001416	65.43	gold quality
brain	UBERON:0000955	65.41	gold quality
skin of leg	UBERON:0001511	64.46	gold quality
thyroid gland	UBERON:0002046	64.11	gold quality
nucleus accumbens	UBERON:0001882	63.63	gold quality
spleen	UBERON:0002106	63.11	gold quality
pituitary gland	UBERON:0000007	61.32	gold quality
upper lobe of left lung	UBERON:0008952	60.68	gold quality
colon	UBERON:0001155	60.45	gold quality
left ovary	UBERON:0002119	60.34	gold quality
ovary	UBERON:0000992	60.33	gold quality
prostate gland	UBERON:0002367	55.97	gold quality
right testis	UBERON:0004534	50.64	gold quality
left testis	UBERON:0004533	46.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.97

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 27)

• Alterations of miR571 and miR-652 serum levels in patients with chronic liver disease reflect their putative roles in the mediation of fibrogenic and inflammatory processes in distinct cellular compartments involved in the pathogenesis of liver cirrhosis. (PMID:22412969)
• Circulating miR-127-3p, miR-376a and miR-652 were found to be associated with breast cancer. (PMID:24194846)
• In acute coronary syndrome patients, circulating miR-652 was found to be a novel candidate biomarker for prognosis. (PMID:25124998)
• In addition to a rather general myeloid regulator miR-223, two other miRNAs seem to be useful subjects in understanding of myeloid miRNA biology: miR-27a and miR-652. [review] (PMID:25177699)
• study showed that the mir652 up regulation in patient with bipolar disorders. (PMID:25708817)
• Results indicate that the combination of miR-652 + miR-660 and Cyfra21-1 has the potential to help in the diagnosis of non-small cell lung carcinoma. (PMID:26213369)
• Data show that microRNA miR-652 was decreased in pancreatic cancer (PC) tissues and antagonistically correlated with zinc finger E-box binding homeobox 1 protein (ZEB1) expression, associating with late tumor stage. (PMID:26498682)
• Serum levels of miR-627, miR-629 and miR-652 were significantly higher in gastric cancer patients than healthy controls. (PMID:26607322)
• these results revealed that miR-652-3p execute a tumor-promoter function in non-small cell lung cancer through direct binding and regulating the expression of Lgl1 (PMID:26934648)
• Data suggest that expression of microRNA-143-3p and microRNA-652-3p in adipocytes is related to insulin resistance; here, expression of microRNA-143-3p and microRNA-652-3p in subcutaneous abdominal white adipocytes is positively associated with insulin-stimulated lipogenesis independent of body mass index. (PMID:28270439)
• High miR652 expression is associated with esophageal squamous cell carcinoma. (PMID:28677800)
• results suggested that a low level of miR-652-3p might be involved in the pathogenesis of pediatric ALL (PMID:29967774)
• MicroRNA-652-3p promotes the proliferation and invasion of the trophoblast HTR-8/SVneo cell line by targeting homeobox A9 to modulate the expression of ephrin receptor B4 (PMID:30839116)
• MiR-652 was significantly elevated in gastric cancer (GC) tissues and cell lines and the expression level of miR-652 was significantly associated with TNM stage and lymph node metastasis. GC patients with high expression of miR-652 had a shorter overall survival rate. Overexpressing miR-652 could enhance cell proliferation, migration and invasion. RORA was proved to be the target gene of miR-652. (PMID:31524147)
• MiR-652-3p promotes bladder cancer migration and invasion by targeting KCNN3. (PMID:31696467)
• The direct regulation of HOXA9 by miR-652 was experimentally validated in uveal melanoma cells by dual luciferase assay and Western blotting. Authors also observed that miR-652 promoted HIF-1alpha signaling via repression of HOXA9 in uveal melanoma cells. (PMID:31740654)
• CircRNA_MYLK promotes malignant progression of ovarian cancer through regulating microRNA-652. (PMID:32495861)
• A Five-microRNA Signature as Risk Stratification System in Uterine Corpus Endometrial Carcinoma. (PMID:32748742)
• Diagnostic and prognostic significance of aberrant miR-652-3p levels in patients with acute decompensated heart failure and acute kidney injury. (PMID:33249927)
• Upregulation of microRNA miR-652-3p is a prognostic risk factor for hepatocellular carcinoma and regulates cell proliferation, migration, and invasion. (PMID:34608826)
• Characterization of plasma exosomal microRNAs in responding to radiotherapy of human esophageal squamous cell carcinoma. (PMID:35894132)
• Inhibition of miR-652-3p Regulates Lipid Metabolism and Inflammatory Cytokine Secretion of Macrophages to Alleviate Atherosclerosis by Improving TP53 Expression. (PMID:36248191)
• Regulation of the Placental Growth Factor Mediated by Sumoylation and Expression of miR-652-3p in Pregnant Women with Early-Onset Preeclampsia. (PMID:36437340)
• MiR-652-3p promotes malignancy and metastasis of cancer cells via inhibiting TNRC6A in hepatocellular carcinoma. (PMID:36495604)
• Association of MicroRNA-652 Expression with Radiation Response of Colorectal Cancer: A Study from Rectal Cancer Patients in a Swedish Trial of Preoperative Radiotherapy. (PMID:37076469)
• Hypoxic BMSC-derived exosomal miR-652-3p promotes proliferation and metastasis of hepatocarcinoma cancer cells via targeting TNRC6A. (PMID:37976119)
• Circ_0012152 Accelerates Acute Myeloid Leukemia Progression through the miR-652-3p/SOX4 Axis. (PMID:38842772)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir652	ENSMUSG00000076011
rattus_norvegicus	Mir652	ENSRNOG00000040458

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.