MIR653

Summary

MIR653 (microRNA 653, HGNC:32909) is a microRNA gene on chromosome 7q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 724023 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32909
Approved symbol	MIR653
Name	microRNA 653
Location	7q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-653
Ensembl gene	ENSG00000208014
Ensembl biotype	miRNA
Entrez	724023
RNAcentral	URS00006F04EF — miRNA, 96 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385279

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385279 — 1 exons

Exon	Start	End
ENSE00001500285	93482760	93482855

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 71.99.

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of uterus	UBERON:0009853	71.99	gold quality
heart left ventricle	UBERON:0002084	71.95	gold quality
heart	UBERON:0000948	71.09	gold quality
tibial artery	UBERON:0007610	68.89	gold quality
esophagus mucosa	UBERON:0002469	68.55	gold quality
myometrium	UBERON:0001296	67.58	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.38	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.98	gold quality
vagina	UBERON:0000996	64.92	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.98	gold quality
pituitary gland	UBERON:0000007	61.88	gold quality
tibial nerve	UBERON:0001323	60.09	gold quality
prostate gland	UBERON:0002367	59.89	gold quality
lung	UBERON:0002048	59.54	gold quality
colon	UBERON:0001155	51.10	gold quality
left testis	UBERON:0004533	50.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• Mechanically, bioinformatics analysis predicted that miR-653-5p was the shared partner of lncRNA SNHG7 and signal transducer and activator of transcription 2 (STAT2) in a feedback loop regulating neuroblastoma progression. (PMID:30623419)
• ciRs-6 upregulates March1 to suppress bladder cancer growth by sponging miR-653. (PMID:31819015)
• SOX30 upregulation due to miR-653-5p inhibition restricted the proliferation and invasion of prostate cancer cells, and this was associated with Wnt/ CTNNB1 signaling suppression. (PMID:31889959)
• LINC00858 facilitates the malignant development of Wilms’ Tumor by targeting miR-653-5p. (PMID:32538587)
• Long noncoding RNA PLK1S1 was associated with renal cell carcinoma progression by interacting with microRNA653 and altering CXC chemokine receptor 5 expression. (PMID:33000253)
• miR6535p suppresses the growth and migration of breast cancer cells by targeting MAPK6. (PMID:33495824)
• The depletion of Circ-PRKDC enhances autophagy and apoptosis in T-cell acute lymphoblastic leukemia via microRNA-653-5p/Reelin mediation of the PI3K/AKT/mTOR signaling pathway. (PMID:33615686)
• Exosomal circular RNA hsa_circ_007293 promotes proliferation, migration, invasion, and epithelial-mesenchymal transition of papillary thyroid carcinoma cells through regulation of the microRNA-653-5p/paired box 6 axis. (PMID:34866540)
• The emerging role of miR-653 in human cancer. (PMID:35777307)
• Circular circRANGAP1 Contributes to Non-small Cell Lung Cancer Progression by Increasing COL11A1 Expression Through Sponging miR-653-5p. (PMID:37193942)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.