MIR657

Summary

MIR657 (microRNA 657, HGNC:32913) is a microRNA gene on chromosome 17q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 724027 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32913
Approved symbol	MIR657
Name	microRNA 657
Location	17q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-657
Ensembl gene	ENSG00000207736
Ensembl biotype	miRNA
Entrez	724027
RNAcentral	URS000070FFCE — miRNA, 98 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385003

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385003 — 1 exons

Exon	Start	End
ENSE00001500010	81125276	81125373

Expression profiles

Bgee: expression breadth ubiquitous, 106 present calls, max score 97.66.

Top tissues by expression

106 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.66	gold quality
tibial nerve	UBERON:0001323	96.26	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	91.11	gold quality
prefrontal cortex	UBERON:0000451	90.08	gold quality
corpus callosum	UBERON:0002336	89.55	gold quality
Ammon’s horn	UBERON:0001954	88.87	gold quality
substantia nigra	UBERON:0002038	87.34	gold quality
putamen	UBERON:0001874	86.45	gold quality
amygdala	UBERON:0001876	85.77	gold quality
frontal cortex	UBERON:0001870	85.63	gold quality
right frontal lobe	UBERON:0002810	85.52	gold quality
caudate nucleus	UBERON:0001873	85.40	gold quality
blood	UBERON:0000178	84.75	gold quality
duodenum	UBERON:0002114	84.67	gold quality
Brodmann (1909) area 9	UBERON:0013540	83.25	gold quality
hypothalamus	UBERON:0001898	83.11	gold quality
cerebral cortex	UBERON:0000956	83.05	gold quality
brain	UBERON:0000955	82.45	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	82.29	gold quality
right hemisphere of cerebellum	UBERON:0014890	81.99	gold quality
nucleus accumbens	UBERON:0001882	81.46	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	79.91	gold quality
small intestine	UBERON:0002108	79.69	gold quality
cerebellar hemisphere	UBERON:0002245	79.67	gold quality
small intestine Peyer’s patch	UBERON:0003454	79.40	gold quality
skeletal muscle tissue	UBERON:0001134	78.62	gold quality
anterior cingulate cortex	UBERON:0009835	78.54	gold quality
vermiform appendix	UBERON:0001154	77.59	gold quality
multicellular organism	UBERON:0000468	77.10	gold quality
monocyte	CL:0000576	76.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• hsa-miR-657 acts directly at the 3’UTR of the IGF2R. (PMID:18602895)
• MicroRNA-657 promotes tumorigenesis in hepatocellular carcinoma by targeting transducin-like enhancer protein 1 through nuclear factor kappa B pathways. (PMID:23175432)
• Data indicate that the hsa-miR-657-hsa-miR-1287 classifier displayed high sensitivity and specificity for discriminating between early larynx carcinoma and normal mucosa tissues. (PMID:24238754)
• dysregulation of miR-657 contributes to the pathogenesis of gestational diabetes mellitus via IL-37/NF-kappaB signaling axis. (PMID:30362558)
• MicroRNA hsa-miR-657 promotes retinoblastoma malignancy by inhibiting peroxisome proliferator-activated receptor alpha expression. (PMID:35324527)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.