MIR658

Summary

MIR658 (microRNA 658, HGNC:32914) is a microRNA gene on chromosome 22q13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 724028 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32914
Approved symbol	MIR658
Name	microRNA 658
Location	22q13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-658
Ensembl gene	ENSG00000284197
Ensembl biotype	miRNA
Entrez	724028
RNAcentral	URS000075ABB5 — miRNA, 100 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385210

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385210 — 1 exons

Exon	Start	End
ENSE00001500216	37844272	37844371

Expression profiles

Bgee: expression breadth ubiquitous, 105 present calls, max score 88.18.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.1835 / max 26.9185, expressed in 1410 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
194095	2.1835	1410

Top tissues by expression

105 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	88.18	gold quality
skeletal muscle tissue	UBERON:0001134	81.56	gold quality
endometrium	UBERON:0001295	77.85	gold quality
duodenum	UBERON:0002114	77.67	gold quality
descending thoracic aorta	UBERON:0002345	77.21	gold quality
monocyte	CL:0000576	76.82	gold quality
bone marrow	UBERON:0002371	76.63	gold quality
muscle of leg	UBERON:0001383	75.82	gold quality
vermiform appendix	UBERON:0001154	75.51	gold quality
blood	UBERON:0000178	75.18	gold quality
gastrocnemius	UBERON:0001388	75.10	gold quality
islet of Langerhans	UBERON:0000006	74.09	gold quality
adrenal tissue	UBERON:0018303	73.87	gold quality
calcaneal tendon	UBERON:0003701	73.84	gold quality
body of stomach	UBERON:0001161	73.83	gold quality
placenta	UBERON:0001987	73.71	gold quality
right adrenal gland cortex	UBERON:0035827	73.71	gold quality
stomach	UBERON:0000945	73.62	gold quality
granulocyte	CL:0000094	73.47	gold quality
left adrenal gland	UBERON:0001234	73.19	gold quality
liver	UBERON:0002107	72.39	gold quality
adrenal gland	UBERON:0002369	72.26	gold quality
body of pancreas	UBERON:0001150	72.21	gold quality
urinary bladder	UBERON:0001255	72.20	gold quality
fundus of stomach	UBERON:0001160	72.05	gold quality
right atrium auricular region	UBERON:0006631	72.01	gold quality
heart left ventricle	UBERON:0002084	71.94	gold quality
heart	UBERON:0000948	71.83	gold quality
left adrenal gland cortex	UBERON:0035825	71.50	gold quality
right adrenal gland	UBERON:0001233	70.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.26

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.