MIR659

Summary

MIR659 (microRNA 659, HGNC:32915) is a microRNA gene on chromosome 22q13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 724029 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32915
Approved symbol	MIR659
Name	microRNA 659
Location	22q13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-659
Ensembl gene	ENSG00000207696
Ensembl biotype	miRNA
OMIM	613556
Entrez	724029
RNAcentral	URS000075BF23 — miRNA, 97 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384963

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384963 — 1 exons

Exon	Start	End
ENSE00001499970	37847678	37847774

Expression profiles

Bgee: expression breadth ubiquitous, 104 present calls, max score 98.05.

Top tissues by expression

104 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	98.05	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	90.27	gold quality
skeletal muscle tissue	UBERON:0001134	82.41	gold quality
monocyte	CL:0000576	80.28	gold quality
adrenal tissue	UBERON:0018303	78.71	gold quality
islet of Langerhans	UBERON:0000006	75.61	gold quality
smooth muscle tissue	UBERON:0001135	75.43	gold quality
lymph node	UBERON:0000029	74.93	gold quality
bone marrow	UBERON:0002371	74.83	gold quality
blood	UBERON:0000178	74.68	gold quality
muscle of leg	UBERON:0001383	74.35	gold quality
pancreas	UBERON:0001264	73.95	gold quality
gastrocnemius	UBERON:0001388	73.53	gold quality
endocervix	UBERON:0000458	72.91	gold quality
heart left ventricle	UBERON:0002084	72.71	gold quality
body of pancreas	UBERON:0001150	72.20	gold quality
body of stomach	UBERON:0001161	71.80	gold quality
Ammon’s horn	UBERON:0001954	71.80	gold quality
heart	UBERON:0000948	71.79	gold quality
stomach	UBERON:0000945	71.37	gold quality
right adrenal gland	UBERON:0001233	71.20	gold quality
putamen	UBERON:0001874	71.19	gold quality
liver	UBERON:0002107	71.10	gold quality
prefrontal cortex	UBERON:0000451	71.04	gold quality
endometrium	UBERON:0001295	70.92	gold quality
adrenal gland	UBERON:0002369	70.84	gold quality
right lobe of liver	UBERON:0001114	70.69	gold quality
tibial artery	UBERON:0007610	70.26	gold quality
left uterine tube	UBERON:0001303	70.20	gold quality
popliteal artery	UBERON:0002250	70.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Genetic variability in a miR-659 binding-site of GNR increased the risk for TDP-43 positive frontotemporal dementia. (PMID:18723524)
• Thus, our study suggests a role of the focal adhesion pathway, regulated by miR-659-3p through CNOT1, in the human NB metastatic process. (PMID:25980492)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.