MIR662

Summary

MIR662 (microRNA 662, HGNC:32918) is a microRNA gene on chromosome 16p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 724032 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32918
Approved symbol	MIR662
Name	microRNA 662
Location	16p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-662
Ensembl gene	ENSG00000207579
Ensembl biotype	miRNA
Entrez	724032
RNAcentral	URS00006BFF14 — miRNA, 95 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384847

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384847 — 1 exons

Exon	Start	End
ENSE00001499854	770183	770277

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 73.84.

Top tissues by expression

21 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hypothalamus	UBERON:0001898	73.84	gold quality
skin of leg	UBERON:0001511	64.89	gold quality
body of uterus	UBERON:0009853	64.75	gold quality
esophagus mucosa	UBERON:0002469	64.17	gold quality
skin of abdomen	UBERON:0001416	62.87	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.36	gold quality
nucleus accumbens	UBERON:0001882	60.88	gold quality
body of stomach	UBERON:0001161	59.93	gold quality
right frontal lobe	UBERON:0002810	59.70	gold quality
minor salivary gland	UBERON:0001830	59.26	gold quality
upper lobe of left lung	UBERON:0008952	59.21	gold quality
putamen	UBERON:0001874	59.06	gold quality
thoracic mammary gland	UBERON:0005200	58.85	gold quality
lung	UBERON:0002048	58.80	gold quality
left ovary	UBERON:0002119	58.74	gold quality
caudate nucleus	UBERON:0001873	55.09	gold quality
Ammon’s horn	UBERON:0001954	54.50	gold quality
pituitary gland	UBERON:0000007	52.73	gold quality
Brodmann (1909) area 9	UBERON:0013540	51.69	gold quality
left testis	UBERON:0004533	40.04	gold quality
testis	UBERON:0000473	39.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• this study shows that MiR-662 enhances chemoresistance and invasiveness of squamous cell lung carcinoma (PMID:29571988)
• MiR-662 is associated with metastatic relapse in early-stage breast cancer and promotes metastasis by stimulating cancer cell stemness. (PMID:37443350)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.