MIR663B

Summary

MIR663B (microRNA 663b, HGNC:35270) is a microRNA gene on chromosome 2q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313824 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35270
Approved symbol	MIR663B
Name	microRNA 663b
Location	2q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-663b
Ensembl gene	ENSG00000221288
Ensembl biotype	miRNA
Entrez	100313824
RNAcentral	URS000075EE28 — miRNA, 115 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408361

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408361 — 1 exons

Exon	Start	End
ENSE00001807964	132256966	132257080

Expression profiles

Bgee: expression breadth ubiquitous, 119 present calls, max score 99.89.

Top tissues by expression

119 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.89	gold quality
mucosa of transverse colon	UBERON:0004991	98.39	gold quality
lower esophagus mucosa	UBERON:0035834	96.76	gold quality
adrenal tissue	UBERON:0018303	94.85	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	94.76	gold quality
liver	UBERON:0002107	93.99	gold quality
right testis	UBERON:0004534	93.19	gold quality
right lobe of liver	UBERON:0001114	93.08	gold quality
tibial nerve	UBERON:0001323	92.72	gold quality
left testis	UBERON:0004533	92.71	gold quality
subcutaneous adipose tissue	UBERON:0002190	92.61	gold quality
blood	UBERON:0000178	92.08	gold quality
hindlimb stylopod muscle	UBERON:0004252	91.51	gold quality
testis	UBERON:0000473	91.45	gold quality
adult mammalian kidney	UBERON:0000082	91.22	gold quality
thoracic mammary gland	UBERON:0005200	91.19	gold quality
calcaneal tendon	UBERON:0003701	91.06	gold quality
cortex of kidney	UBERON:0001225	91.05	gold quality
ectocervix	UBERON:0012249	90.92	gold quality
right hemisphere of cerebellum	UBERON:0014890	90.67	gold quality
adipose tissue	UBERON:0001013	90.59	gold quality
prostate gland	UBERON:0002367	90.45	gold quality
skin of abdomen	UBERON:0001416	90.42	gold quality
kidney	UBERON:0002113	90.22	gold quality
minor salivary gland	UBERON:0001830	90.18	gold quality
metanephros cortex	UBERON:0010533	90.13	gold quality
saliva-secreting gland	UBERON:0001044	89.83	gold quality
zone of skin	UBERON:0000014	89.72	gold quality
skin of leg	UBERON:0001511	89.27	gold quality
right lobe of thyroid gland	UBERON:0001119	89.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.07

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 14)

• Circulating level of miR-663b is associated with acute myocardial infarction. (PMID:24885383)
• Results showed that MIR219-2, MIR663b and MIR1237 were transcriptionally silenced by DNA hypermethylation in human gastric cancer cell lines. (PMID:26043902)
• the ability of IL21 to modulate gene and miRNA expressions in CD40-activated Chronic Lymphocytic Leukemiacells, was studied. (PMID:26305332)
• Studies indicate that miR-663b is epigenetically repressed by long non-coding RNA HOTAIR and exerts its tumor-suppressive function via targeting insulin-like growth factor 2 (IGF2) in pancreatic cancer. (PMID:27895308)
• the present study verified a novel molecular link between miRNA663b and TP73, and indicated that miRNA663b may be a critical therapeutic target in breast cancer. (PMID:29845295)
• The restoration of miR-663b expression inhibited cell proliferation and invasion in HCC through directly targeting and inhibiting GAB2. (PMID:30720118)
• High miR663b expression is associated with bladder cancer. (PMID:30896880)
• SNHG8 was up-regulated in colorectal cancer and promoted the proliferation, migration, and invasion of colorectal cancer by sponging miR-663. (PMID:31152930)
• Exosomal miR-663b targets Ets2-repressor factor to promote proliferation and the epithelial-mesenchymal transition of bladder cancer cells. (PMID:31872468)
• Expression of miR-18a-5p, miR-144-3p, and miR-663b in colorectal cancer and their association with cholesterol homeostasis. (PMID:33465419)
• Exosomal miR663b exposed to TGFbeta1 promotes cervical cancer metastasis and epithelialmesenchymal transition by targeting MGAT3. (PMID:33649791)
• Circular RNA hsa_circ_0008896 accelerates atherosclerosis by promoting the proliferation, migration and invasion of vascular smooth muscle cells via hsa-miR-633/CDC20B (cell division cycle 20B) axis. (PMID:35212610)
• Exosomal miR-663b from “M1” macrophages promotes pulmonary artery vascular smooth muscle cell dysfunction through inhibiting the AMPK/Sirt1 axis. (PMID:37142272)
• The effect of microRNA-663b in the inhibition of interleukin-1-induced nucleus pulposus cell apoptosis and inflammatory response. (PMID:37245236)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.