MIR668

Summary

MIR668 (microRNA 668, HGNC:33135) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 768214 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33135
Approved symbol	MIR668
Name	microRNA 668
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-668
Ensembl gene	ENSG00000276352
Ensembl biotype	miRNA
Entrez	768214
RNAcentral	URS00006F5B1B — miRNA, 66 nt, 22 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000611970

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000611970 — 1 exons

Exon	Start	End
ENSE00003727033	101055258	101055323

Expression profiles

Bgee: expression breadth broad, 41 present calls, max score 98.10.

Top tissues by expression

41 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	98.10	gold quality
stomach	UBERON:0000945	94.34	gold quality
blood	UBERON:0000178	84.23	gold quality
heart	UBERON:0000948	81.00	gold quality
Ammon’s horn	UBERON:0001954	80.66	gold quality
lung	UBERON:0002048	80.49	gold quality
placenta	UBERON:0001987	79.04	gold quality
intestine	UBERON:0000160	78.16	gold quality
kidney	UBERON:0002113	77.13	gold quality
calcaneal tendon	UBERON:0003701	76.00	gold quality
colon	UBERON:0001155	74.00	gold quality
monocyte	CL:0000576	73.73	gold quality
adult mammalian kidney	UBERON:0000082	73.51	gold quality
prefrontal cortex	UBERON:0000451	72.66	gold quality
islet of Langerhans	UBERON:0000006	72.30	gold quality
transverse colon	UBERON:0001157	70.24	gold quality
left ovary	UBERON:0002119	69.94	gold quality
left adrenal gland cortex	UBERON:0035825	69.94	gold quality
left adrenal gland	UBERON:0001234	68.97	gold quality
liver	UBERON:0002107	68.76	gold quality
right adrenal gland	UBERON:0001233	68.48	gold quality
small intestine Peyer’s patch	UBERON:0003454	67.82	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.53	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.36	gold quality
omental fat pad	UBERON:0010414	65.64	gold quality
skin of abdomen	UBERON:0001416	64.98	gold quality
Brodmann (1909) area 9	UBERON:0013540	64.02	gold quality
body of uterus	UBERON:0009853	63.98	gold quality
frontal cortex	UBERON:0001870	63.95	gold quality
anterior cingulate cortex	UBERON:0009835	63.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• miR-668 was upregulated in radioresistant human breast cancer cell lines MCF-7R and T-47DR, which targeted IkappaBalpha, activated the NF-kappaB pathway and thus increased the radioresistance of breast cancer cells. (PMID:28138801)
• the results suggest that miR-668 is induced via HIF-1 in ischemic AKI and that, upon induction, miR-668 represses MTP18 to preserve mitochondrial dynamics for renal tubular cell survival and kidney protection. (PMID:30325740)
• Upregulated circTMEM59 Inhibits Cell Growth and Metastasis by miR-668-3p/ID4 Axis in Colorectal Cancer. (PMID:35656024)
• The miR-668 binding site variant rs1046322 on WFS1 is associated with obesity in Southeast Asians. (PMID:37859980)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir668	ENSMUSG00000099236

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.