MIR670

Summary

MIR670 (microRNA 670, HGNC:37304) is a microRNA gene on chromosome 11p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313777 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37304
Approved symbol	MIR670
Name	microRNA 670
Location	11p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-670
Ensembl gene	ENSG00000211568
Ensembl biotype	miRNA
Entrez	100313777
RNAcentral	URS000075B3C7 — miRNA, 98 nt, 14 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390142

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390142 — 1 exons

Exon	Start	End
ENSE00001507569	43559656	43559753

Expression profiles

Bgee: expression breadth broad, 42 present calls, max score 83.46.

Top tissues by expression

42 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	83.46	gold quality
blood	UBERON:0000178	78.36	gold quality
stomach	UBERON:0000945	76.95	gold quality
islet of Langerhans	UBERON:0000006	76.46	gold quality
heart left ventricle	UBERON:0002084	75.98	gold quality
prefrontal cortex	UBERON:0000451	71.03	gold quality
skin of leg	UBERON:0001511	70.52	gold quality
nucleus accumbens	UBERON:0001882	70.40	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.63	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.12	gold quality
substantia nigra	UBERON:0002038	68.05	gold quality
body of pancreas	UBERON:0001150	67.79	gold quality
putamen	UBERON:0001874	67.33	gold quality
anterior cingulate cortex	UBERON:0009835	67.28	gold quality
cerebral cortex	UBERON:0000956	67.02	gold quality
left ovary	UBERON:0002119	66.82	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.80	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.74	gold quality
corpus callosum	UBERON:0002336	66.65	gold quality
ovary	UBERON:0000992	66.53	gold quality
cerebellar hemisphere	UBERON:0002245	66.44	gold quality
frontal cortex	UBERON:0001870	66.24	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.16	gold quality
left adrenal gland cortex	UBERON:0035825	66.14	gold quality
myometrium	UBERON:0001296	65.78	gold quality
right frontal lobe	UBERON:0002810	65.70	gold quality
spleen	UBERON:0002106	65.58	gold quality
Ammon’s horn	UBERON:0001954	65.10	gold quality
vagina	UBERON:0000996	64.93	gold quality
amygdala	UBERON:0001876	64.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• Findings suggest the involvement of hsa-miR-670 during Intrahepatic cholangiocarcinoma tumour progression and differentiation. and differentiation. (PMID:25017828)
• Circ-ABCB10 promotes proliferation and invasion of esophageal squamous cell carcinoma cells by modulating microRNA-670-3p. (PMID:32572924)
• Circular RNA SMARCA5 suppressed non-small cell lung cancer progression by regulating miR-670-5p/RBM24 axis. (PMID:33085761)
• PP7080 expedites the proliferation and migration of lung adenocarcinoma cells via sponging miR-670-3p and regulating UHRF1BP1. (PMID:33844396)
• MicroRNA-670-3p suppresses ferroptosis of human glioblastoma cells through targeting ACSL4. (PMID:34323631)
• [Effects of miR-670-5p on proliferation, migration and invasion of lung cancer cells]. (PMID:34816661)
• CircFAM188A Regulates Autophagy via miR-670-3p and ULK1 in Epithelial Ovarian Carcinoma. (PMID:39229655)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.