MIR671

Summary

MIR671 (microRNA 671, HGNC:33134) is a microRNA gene on chromosome 7q36.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 768213 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33134
Approved symbol	MIR671
Name	microRNA 671
Location	7q36.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-671
Ensembl gene	ENSG00000284191
Ensembl biotype	miRNA
OMIM	615245
Entrez	768213
RNAcentral	URS000075DC96 — miRNA, 118 nt, 19 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390183

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390183 — 1 exons

Exon	Start	End
ENSE00001507610	151238421	151238538

Expression profiles

Bgee: expression breadth broad, 37 present calls, max score 88.46.

Top tissues by expression

37 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
anterior cingulate cortex	UBERON:0009835	88.46	gold quality
skin of leg	UBERON:0001511	79.65	gold quality
blood	UBERON:0000178	78.21	gold quality
skeletal muscle tissue	UBERON:0001134	73.48	gold quality
left ovary	UBERON:0002119	73.00	gold quality
ovary	UBERON:0000992	72.99	gold quality
heart left ventricle	UBERON:0002084	72.96	gold quality
liver	UBERON:0002107	72.86	gold quality
right frontal lobe	UBERON:0002810	72.03	gold quality
adult mammalian kidney	UBERON:0000082	71.78	gold quality
tibial artery	UBERON:0007610	71.74	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.99	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.52	gold quality
hypothalamus	UBERON:0001898	69.93	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.78	gold quality
right hemisphere of cerebellum	UBERON:0014890	69.44	gold quality
tibial nerve	UBERON:0001323	69.15	gold quality
gastrocnemius	UBERON:0001388	68.95	gold quality
muscle of leg	UBERON:0001383	68.83	gold quality
omental fat pad	UBERON:0010414	68.27	gold quality
brain	UBERON:0000955	64.67	gold quality
nucleus accumbens	UBERON:0001882	64.23	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.11	gold quality
myometrium	UBERON:0001296	63.99	gold quality
intestine	UBERON:0000160	63.95	gold quality
left lobe of thyroid gland	UBERON:0001120	63.77	gold quality
cerebellar hemisphere	UBERON:0002245	63.74	gold quality
duodenum	UBERON:0002114	63.14	gold quality
upper lobe of left lung	UBERON:0008952	61.10	gold quality
left testis	UBERON:0004533	60.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 36)

• Data show up-regulation of hsa-miR-720 and hsa-miR-21, and down-regulation of hsa-miR-671-5p. (PMID:21649547)
• miR-671 directs cleavage of a circular antisense transcript of the Cerebellar Degeneration-Related protein 1 (CDR1) locus in an Ago2-slicer-dependent manner. (PMID:21964070)
• Data indicate that microRNA miR-671-5p functions as a tumor suppressor in breast cancer by directly targeting forkhead box M1 (FOXM1). (PMID:26588055)
• overexpression of miR-671-5p is associated with glioblastoma multiforme. (PMID:26683098)
• Our results suggest a general role of miR-206,-381, and 671-5p in SMARCB1 gene silencing of epithelioid sarcomas(ES) , extraskeletal myxoid chondrosarcomas , malignant peripheral nerve sheath tumors and synovial sarcomas . In the future, miR-765 could possibly be a diagnostic tool for ES because of its 97% specificity and 80% sensitivity. (PMID:27223121)
• miR-671-5p- and miR-193a-5p-mediated epigenetic mode of SMARCB1/INI1 loss and downregulated TGF-beta pathway in childhood chordomas. (PMID:28825187)
• Results reveal that miR-33b, miR-671, and miR-140 are significantly downregulated in the serum of osteoarthritis patients. (PMID:29255496)
• miR-671 promotes prostate cancer cell proliferation by inhibiting SOX6 (PMID:29355560)
• Results showed that the expression level of miR671 was lower in breast cancer (BC) tissues and suggest that it may function as a tumor suppressor in BC by influencing the Wnt signaling cascade. (PMID:29620195)
• TUFT1 promoted the growth, metastasis and EMT of hepatocellular carcinoma (HCC) cells through activating Ca(2+)/PI3K/AKT pathway. The hypoxic microenvironment increased the expression of TUFT1 via downregulation of miR-671-5p. TUFT1 may function as a potential therapeutic target for the intervention and treatment of HCC. (PMID:30250300)
• the present study demonstrated that miR6713p exerted its tumorsuppressive roles via directly targeting CCND2 in nonsmall cell lung cancer (PMID:30664171)
• Downregulated miR-671 may influence the level of ciRS-7 in rheumatoid arthritis (RA) patients. Enhanced ciRS-7 could inhibit the function of miR-7 and further relieve the inhibitory effect of miR-7 on mTOR. (PMID:30711014)
• miR-671 was downregulated in osteoarthritis tissues, plasma and IL-1beta treated CHON-001 cells, compared with controls. (PMID:31085006)
• TRAF3 as a functional target of miR-671-3p. (PMID:31322228)
• Long noncoding RNA DLEU1 aggravates osteosarcoma carcinogenesis via regulating the miR-671-5p/DDX5 axis (PMID:31379208)
• miR-671-5p displays a dynamic decrease expression during the oncogenic transition of BC by suppressing FOXM1-mediated EMT and DNA repair. Therefore, miR-671-5p may serve as a novel biomarker for early BC detection as well as a therapeutic target for BC management. (PMID:31391072)
• miR-671 directly binds to CCND1 and CDC34, inhibits cell proliferation and osteosarcoma progression. (PMID:31393166)
• miR-671-5p was upregulated in clear cell renal cell carcinoma (ccRCC) compared with paracarcinoma and correlated with poor prognosis of ccRCC patients (PMID:31686521)
• MiR-671-5p plays a promising role in restraining osteosarcoma cell characteristics through targeting TUFT1. (PMID:32115852)
• MiR-671-3p suppresses the proliferation and invasion of breast cancer cell line MCF-7 by directly targeting DEPTOR protein. (PMID:32376551)
• Guizhi Fuling pills inhibit the proliferation, migration and invasion of human cutaneous malignant melanoma cells by regulating the molecular axis of LncRNA TPT1-AS1 / miR-671-5p. (PMID:33040829)
• MiRNA-671-5p Promotes prostate cancer development and metastasis by targeting NFIA/CRYAB axis. (PMID:33144585)
• circSLC8A1 sponges miR-671 to regulate breast cancer tumorigenesis via PTEN/PI3k/Akt pathway. (PMID:33301895)
• Circ_0114876 promoted IL-1beta-induced chondrocyte injury by targeting miR-671/TRAF2 axis. (PMID:33404903)
• miR-720 is a key regulator of glioma migration and invasion by controlling TARSL2 expression. (PMID:34024034)
• miR-671-5p repressed progression of papillary thyroid carcinoma via TRIM14. (PMID:34292652)
• [MiR-671-5p negatively regulates SMAD3 to inhibit migration and invasion of osteosarcoma cells]. (PMID:34755673)
• Circ_0001947 promotes cell proliferation, invasion, migration and inflammation and inhibits apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes through miR-671-5p/STAT3 axis. (PMID:35093109)
• LncRNA-PACERR induces pro-tumour macrophages via interacting with miR-671-3p and m6A-reader IGF2BP2 in pancreatic ductal adenocarcinoma. (PMID:35526050)
• lncRNA DLEU1 Modulates Proliferation, Inflammation, and Extracellular Matrix Degradation of Chondrocytes through Regulating miR-671-5p. (PMID:35647200)
• Extracellular vesicle-transmitted miR-671-5p alleviates lung inflammation and injury by regulating the AAK1/NF-kappaB axis. (PMID:36733250)
• The molecular mechanism of gamma-aminobutyric acid against AD: the role of CEBPalpha/circAPLP2/miR-671-5p in regulating CNTN1/2 expression. (PMID:36734072)
• Circular RNA circARHGEF28 inhibited the progression of prostate cancer via the miR-671-5p/LGALS3BP/NF-kappaB axis. (PMID:37186007)
• MiR-766-3p and miR-671-5p attenuate aristolochic acid-induced hepatotoxicity by directly targeting the key bioactivating enzyme NQO1. (PMID:37285672)
• CircHDAC9 regulates myocardial ischemia-reperfusion injury via miR-671-5p/SOX4 signaling axis. (PMID:37939881)
• MicroRNA-671-5p regulates the inflammatory response of periodontal ligament stem cells via the DUSP8/p38 MAPK pathway. (PMID:38727958)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir671	ENSMUSG00000076387

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.