MIR6715A

Summary

MIR6715A (microRNA 6715a, HGNC:49996) is a microRNA gene on chromosome 10q25.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466189 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49996
Approved symbol	MIR6715A
Name	microRNA 6715a
Location	10q25.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6715a
Ensembl gene	ENSG00000276857
Ensembl biotype	miRNA
Entrez	102466189
RNAcentral	URS000075D043 — miRNA, 79 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000615929

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000615929 — 1 exons

Exon	Start	End
ENSE00003715667	112299612	112299690

Expression profiles

Bgee: expression breadth broad, 14 present calls, max score 85.94.

Top tissues by expression

14 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	85.94	gold quality
small intestine	UBERON:0002108	82.05	gold quality
endometrium	UBERON:0001295	68.31	gold quality
body of uterus	UBERON:0009853	64.41	gold quality
omental fat pad	UBERON:0010414	63.00	gold quality
transverse colon	UBERON:0001157	62.75	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.57	gold quality
left lobe of thyroid gland	UBERON:0001120	61.53	gold quality
thyroid gland	UBERON:0002046	61.30	gold quality
prostate gland	UBERON:0002367	60.62	gold quality
minor salivary gland	UBERON:0001830	60.45	gold quality
colon	UBERON:0001155	58.21	gold quality
right lobe of thyroid gland	UBERON:0001119	57.01	gold quality
left testis	UBERON:0004533	41.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.