MIR6715B

Summary

MIR6715B (microRNA 6715b, HGNC:50249) is a microRNA gene on chromosome 10q25.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465427 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50249
Approved symbol	MIR6715B
Name	microRNA 6715b
Location	10q25.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6715b
Ensembl gene	ENSG00000283688
Ensembl biotype	miRNA
Entrez	102465427
RNAcentral	URS000075C57B — ncRNA, 77 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637172

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637172 — 1 exons

Exon	Start	End
ENSE00003800289	112299612	112299688

Expression profiles

Bgee: expression breadth broad, 14 present calls, max score 85.72.

Top tissues by expression

14 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	85.72	gold quality
right lobe of liver	UBERON:0001114	78.17	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	71.67	gold quality
caudate nucleus	UBERON:0001873	68.63	gold quality
Ammon’s horn	UBERON:0001954	66.54	gold quality
prostate gland	UBERON:0002367	66.52	gold quality
body of uterus	UBERON:0009853	62.70	gold quality
left lobe of thyroid gland	UBERON:0001120	62.34	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.63	gold quality
transverse colon	UBERON:0001157	60.49	gold quality
thyroid gland	UBERON:0002046	60.42	gold quality
esophagus mucosa	UBERON:0002469	60.03	gold quality
right lobe of thyroid gland	UBERON:0001119	59.25	gold quality
right testis	UBERON:0004534	35.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.