MIR6716

Summary

MIR6716 (microRNA 6716, HGNC:50048) is a microRNA gene on chromosome 11q23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466719 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50048
Approved symbol	MIR6716
Name	microRNA 6716
Location	11q23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6716
Ensembl gene	ENSG00000284246
Ensembl biotype	miRNA
Entrez	102466719
RNAcentral	URS000075BF75 — miRNA, 80 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000613413

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000613413 — 1 exons

Exon	Start	End
ENSE00003741432	118644000	118644079

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 78.09.

Top tissues by expression

38 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stomach	UBERON:0000945	78.09	gold quality
endometrium	UBERON:0001295	70.14	gold quality
body of pancreas	UBERON:0001150	67.87	gold quality
right ovary	UBERON:0002118	66.39	gold quality
right atrium auricular region	UBERON:0006631	66.33	gold quality
left coronary artery	UBERON:0001626	65.85	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.24	gold quality
heart left ventricle	UBERON:0002084	62.88	gold quality
transverse colon	UBERON:0001157	62.56	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.95	gold quality
tibial artery	UBERON:0007610	60.69	gold quality
minor salivary gland	UBERON:0001830	60.53	gold quality
skin of abdomen	UBERON:0001416	60.08	gold quality
small intestine Peyer’s patch	UBERON:0003454	59.84	gold quality
gastrocnemius	UBERON:0001388	59.20	gold quality
omental fat pad	UBERON:0010414	58.92	gold quality
spleen	UBERON:0002106	58.77	gold quality
ascending aorta	UBERON:0001496	58.04	gold quality
substantia nigra	UBERON:0002038	57.97	gold quality
skin of leg	UBERON:0001511	57.49	gold quality
tibial nerve	UBERON:0001323	56.75	gold quality
lower esophagus muscularis layer	UBERON:0035833	56.62	gold quality
left lobe of thyroid gland	UBERON:0001120	56.41	gold quality
right frontal lobe	UBERON:0002810	54.88	gold quality
thoracic mammary gland	UBERON:0005200	54.45	gold quality
caudate nucleus	UBERON:0001873	54.15	gold quality
thyroid gland	UBERON:0002046	53.97	gold quality
nucleus accumbens	UBERON:0001882	53.74	gold quality
prostate gland	UBERON:0002367	53.58	gold quality
subcutaneous adipose tissue	UBERON:0002190	53.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.