MIR6718

Summary

MIR6718 (microRNA 6718, HGNC:50195) is a microRNA gene on chromosome 18p11.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465430 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50195
Approved symbol	MIR6718
Name	microRNA 6718
Location	18p11.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6718
Ensembl gene	ENSG00000275518
Ensembl biotype	miRNA
Entrez	102465430
RNAcentral	URS000075D773 — miRNA, 80 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000616153

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000616153 — 1 exons

Exon	Start	End
ENSE00003721744	3885353	3885432

Expression profiles

Bgee: expression breadth broad, 36 present calls, max score 84.55.

Top tissues by expression

36 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	84.55	gold quality
blood	UBERON:0000178	76.51	gold quality
stomach	UBERON:0000945	75.20	gold quality
monocyte	CL:0000576	73.85	gold quality
thoracic mammary gland	UBERON:0005200	69.72	gold quality
tibial artery	UBERON:0007610	68.97	gold quality
intestine	UBERON:0000160	68.84	gold quality
lung	UBERON:0002048	68.77	gold quality
omental fat pad	UBERON:0010414	66.61	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.58	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.53	gold quality
gall bladder	UBERON:0002110	66.33	gold quality
putamen	UBERON:0001874	64.70	gold quality
ectocervix	UBERON:0012249	64.28	gold quality
right frontal lobe	UBERON:0002810	64.27	gold quality
cerebral cortex	UBERON:0000956	64.00	gold quality
frontal cortex	UBERON:0001870	63.67	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.52	gold quality
substantia nigra	UBERON:0002038	63.28	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.26	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.16	gold quality
left adrenal gland cortex	UBERON:0035825	62.91	gold quality
tibial nerve	UBERON:0001323	62.41	gold quality
skin of leg	UBERON:0001511	62.37	gold quality
cerebellar hemisphere	UBERON:0002245	62.22	gold quality
vagina	UBERON:0000996	61.62	gold quality
pituitary gland	UBERON:0000007	61.58	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.26	gold quality
skin of abdomen	UBERON:0001416	58.90	gold quality
prostate gland	UBERON:0002367	58.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-6718-5p and miR-4329 can be used as potential biomarkers for acute myocardial infarction. (PMID:34338363)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.