MIR6719

Summary

MIR6719 (microRNA 6719, HGNC:50012) is a microRNA gene on chromosome 19q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465974 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50012
Approved symbol	MIR6719
Name	microRNA 6719
Location	19q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6719
Ensembl gene	ENSG00000277759
Ensembl biotype	miRNA
Entrez	102465974
RNAcentral	URS000075DA60 — miRNA, 87 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622428

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622428 — 1 exons

Exon	Start	End
ENSE00003726226	39829716	39829802

Expression profiles

Bgee: expression breadth ubiquitous, 109 present calls, max score 88.11.

Top tissues by expression

109 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	88.11	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.06	gold quality
duodenum	UBERON:0002114	81.05	gold quality
adrenal tissue	UBERON:0018303	80.92	gold quality
bone marrow	UBERON:0002371	80.85	gold quality
lymph node	UBERON:0000029	80.28	gold quality
right uterine tube	UBERON:0001302	78.98	gold quality
endometrium	UBERON:0001295	78.81	gold quality
right adrenal gland cortex	UBERON:0035827	78.38	gold quality
vermiform appendix	UBERON:0001154	78.33	gold quality
blood	UBERON:0000178	78.10	gold quality
smooth muscle tissue	UBERON:0001135	78.09	gold quality
muscle of leg	UBERON:0001383	77.95	gold quality
monocyte	CL:0000576	77.54	gold quality
right adrenal gland	UBERON:0001233	77.00	gold quality
granulocyte	CL:0000094	76.79	gold quality
left adrenal gland cortex	UBERON:0035825	76.66	gold quality
gastrocnemius	UBERON:0001388	76.37	gold quality
left uterine tube	UBERON:0001303	76.35	gold quality
right lobe of thyroid gland	UBERON:0001119	75.94	gold quality
placenta	UBERON:0001987	75.80	gold quality
left lobe of thyroid gland	UBERON:0001120	75.76	gold quality
calcaneal tendon	UBERON:0003701	75.44	gold quality
left adrenal gland	UBERON:0001234	75.10	gold quality
thyroid gland	UBERON:0002046	74.97	gold quality
islet of Langerhans	UBERON:0000006	74.92	gold quality
tonsil	UBERON:0002372	73.93	gold quality
urinary bladder	UBERON:0001255	73.74	gold quality
endocervix	UBERON:0000458	73.69	gold quality
skin of abdomen	UBERON:0001416	73.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.21

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.