MIR6720

Summary

MIR6720 (microRNA 6720, HGNC:50032) is a microRNA gene on chromosome 6p25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466720 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50032
Approved symbol	MIR6720
Name	microRNA 6720
Location	6p25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6720
Ensembl gene	ENSG00000275859
Ensembl biotype	miRNA
Entrez	102466720
RNAcentral	URS000075E43D — ncRNA, 98 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000611664

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000611664 — 1 exons

Exon	Start	End
ENSE00003747366	1390314	1390411

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 72.40.

Top tissues by expression

46 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart left ventricle	UBERON:0002084	72.40	gold quality
muscle of leg	UBERON:0001383	72.38	gold quality
upper lobe of left lung	UBERON:0008952	71.44	gold quality
gastrocnemius	UBERON:0001388	69.59	gold quality
ascending aorta	UBERON:0001496	68.72	gold quality
body of pancreas	UBERON:0001150	67.64	gold quality
prefrontal cortex	UBERON:0000451	67.43	gold quality
left adrenal gland cortex	UBERON:0035825	66.91	gold quality
body of stomach	UBERON:0001161	66.39	gold quality
myometrium	UBERON:0001296	65.93	gold quality
left adrenal gland	UBERON:0001234	65.33	gold quality
tibial artery	UBERON:0007610	65.14	gold quality
vagina	UBERON:0000996	65.06	gold quality
blood	UBERON:0000178	64.83	gold quality
right atrium auricular region	UBERON:0006631	64.46	gold quality
putamen	UBERON:0001874	62.15	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.99	gold quality
esophagus mucosa	UBERON:0002469	60.51	gold quality
fallopian tube	UBERON:0003889	59.73	gold quality
cerebellar hemisphere	UBERON:0002245	59.00	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	57.79	gold quality
amygdala	UBERON:0001876	57.49	gold quality
endocervix	UBERON:0000458	57.31	gold quality
minor salivary gland	UBERON:0001830	57.28	gold quality
thoracic mammary gland	UBERON:0005200	56.94	gold quality
left ovary	UBERON:0002119	56.89	gold quality
left lobe of thyroid gland	UBERON:0001120	56.86	gold quality
body of uterus	UBERON:0009853	56.61	gold quality
prostate gland	UBERON:0002367	56.19	gold quality
brain	UBERON:0000955	56.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long non-coding RNA MEG3 inhibits neovascularization in diabetic retinopathy by regulating microRNA miR-6720-5p and cytochrome B5 reductase 2. (PMID:34978518)
• Long Noncoding RNA ACTA2-AS1 Inhibits Cell Growth and Facilitates Apoptosis in Gastric Cancer by Binding with miR-6720-5p to Regulate ESRRB. (PMID:37222961)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.