MIR6721

Summary

MIR6721 (microRNA 6721, HGNC:50049) is a microRNA gene on chromosome 6p21.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466190 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50049
Approved symbol	MIR6721
Name	microRNA 6721
Location	6p21.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6721
Ensembl gene	ENSG00000284469
Ensembl biotype	miRNA
Entrez	102466190
RNAcentral	URS000075D15B — miRNA, 87 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617181

RefSeq mRNA: 0

Canonical transcript exons

ENST00000617181 — 1 exons

Exon	Start	End
ENSE00003747654	32170030	32170116

Expression profiles

Bgee: expression breadth broad, 87 present calls, max score 94.86.

Highest expression (Bgee): sural nerve, placenta, muscle of leg, blood, gastrocnemius.

Top tissues by expression

87 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	94.86	gold quality
placenta	UBERON:0001987	75.40	gold quality
muscle of leg	UBERON:0001383	74.52	gold quality
blood	UBERON:0000178	74.43	gold quality
gastrocnemius	UBERON:0001388	73.32	gold quality
gall bladder	UBERON:0002110	72.80	gold quality
islet of Langerhans	UBERON:0000006	72.60	gold quality
descending thoracic aorta	UBERON:0002345	71.69	gold quality
fundus of stomach	UBERON:0001160	70.91	gold quality
kidney	UBERON:0002113	70.61	gold quality
endocervix	UBERON:0000458	70.36	gold quality
heart left ventricle	UBERON:0002084	70.13	gold quality
heart	UBERON:0000948	70.11	gold quality
right atrium auricular region	UBERON:0006631	70.00	gold quality
metanephros cortex	UBERON:0010533	69.99	gold quality
adult mammalian kidney	UBERON:0000082	69.38	gold quality
body of pancreas	UBERON:0001150	69.24	gold quality
stomach	UBERON:0000945	68.93	gold quality
urinary bladder	UBERON:0001255	68.71	gold quality
smooth muscle tissue	UBERON:0001135	68.57	gold quality
right lobe of liver	UBERON:0001114	68.02	gold quality
liver	UBERON:0002107	67.99	gold quality
endometrium	UBERON:0001295	67.96	gold quality
popliteal artery	UBERON:0002250	67.89	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.79	gold quality
tibial artery	UBERON:0007610	67.79	gold quality
left coronary artery	UBERON:0001626	67.70	gold quality
body of stomach	UBERON:0001161	67.52	gold quality
prefrontal cortex	UBERON:0000451	67.45	gold quality
right frontal lobe	UBERON:0002810	67.13	gold quality
thoracic aorta	UBERON:0001515	66.91	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.86	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.78	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.76	gold quality
ascending aorta	UBERON:0001496	66.72	gold quality
left adrenal gland cortex	UBERON:0035825	66.67	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.64	gold quality
left adrenal gland	UBERON:0001234	66.62	gold quality
lymph node	UBERON:0000029	66.61	gold quality
transverse colon	UBERON:0001157	66.57	gold quality
omental fat pad	UBERON:0010414	66.53	gold quality
colon	UBERON:0001155	66.48	gold quality
apex of heart	UBERON:0002098	66.34	gold quality
body of uterus	UBERON:0009853	66.05	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.95	gold quality
myometrium	UBERON:0001296	65.90	gold quality
putamen	UBERON:0001874	65.86	gold quality
adipose tissue	UBERON:0001013	65.84	gold quality
anterior cingulate cortex	UBERON:0009835	65.59	gold quality
cerebellar hemisphere	UBERON:0002245	65.50	gold quality
left ovary	UBERON:0002119	65.45	gold quality
esophagus mucosa	UBERON:0002469	65.38	gold quality
Ammon’s horn	UBERON:0001954	65.34	gold quality
vagina	UBERON:0000996	65.31	gold quality
small intestine	UBERON:0002108	65.18	gold quality
ovary	UBERON:0000992	65.12	gold quality
substantia nigra	UBERON:0002038	65.04	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.04	gold quality
hypothalamus	UBERON:0001898	65.02	gold quality
multicellular organism	UBERON:0000468	64.86	gold quality
right adrenal gland	UBERON:0001233	64.84	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.80	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.77	gold quality
skin of abdomen	UBERON:0001416	64.70	gold quality
minor salivary gland	UBERON:0001830	64.31	gold quality
skin of leg	UBERON:0001511	63.62	gold quality
thoracic mammary gland	UBERON:0005200	63.57	gold quality
pituitary gland	UBERON:0000007	63.38	gold quality
amygdala	UBERON:0001876	63.25	gold quality
right adrenal gland cortex	UBERON:0035827	63.19	gold quality
adenohypophysis	UBERON:0002196	63.10	gold quality
tibial nerve	UBERON:0001323	63.07	gold quality
lung	UBERON:0002048	62.96	gold quality
right lobe of thyroid gland	UBERON:0001119	62.70	gold quality
left lobe of thyroid gland	UBERON:0001120	62.70	gold quality
nucleus accumbens	UBERON:0001882	62.47	gold quality
spleen	UBERON:0002106	62.22	gold quality
thyroid gland	UBERON:0002046	62.08	gold quality
ectocervix	UBERON:0012249	61.48	gold quality
prostate gland	UBERON:0002367	60.56	gold quality
right ovary	UBERON:0002118	60.12	gold quality
caudate nucleus	UBERON:0001873	60.01	gold quality
upper lobe of left lung	UBERON:0008952	59.08	gold quality
right testis	UBERON:0004534	51.24	gold quality
testis	UBERON:0000473	50.80	gold quality
left testis	UBERON:0004533	50.54	gold quality
corpus callosum	UBERON:0002336	41.95	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
PPT2-EGFL8	ncRNA	100532746
AGPAT1	protein-coding	10554
ATF6B	protein-coding	1388
FKBPL	protein-coding	63943
PRRT1	protein-coding	80863
EGFL8	protein-coding	80864
PPT2	protein-coding	9374
MIR6833	ncRNA	102465500
RNF5	protein-coding	6048
AGER	protein-coding	177
PBX2	protein-coding	5089
NOTCH4	protein-coding	4855
GPSM3	protein-coding	63940

Protein

Non-coding RNA — no protein product.

Function

Gene-set membership (MSigDB)

This non-coding RNA is a member of 1 curated MSigDB gene set — regulatory-target and signature collections that include it (it has no protein-based pathway / GO / interaction data).

chr6p21

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No curated drug or pharmacology associations for this gene.