MIR6722

Summary

MIR6722 (microRNA 6722, HGNC:49927) is a microRNA gene on chromosome 9q34.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465431 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49927
Approved symbol	MIR6722
Name	microRNA 6722
Location	9q34.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6722
Ensembl gene	ENSG00000278756
Ensembl biotype	miRNA
Entrez	102465431
RNAcentral	URS000075E13B — miRNA, 78 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617286

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617286 — 1 exons

Exon	Start	End
ENSE00003739254	136746893	136746970

Expression profiles

Bgee: expression breadth broad, 75 present calls, max score 87.24.

Top tissues by expression

75 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	87.24	gold quality
monocyte	CL:0000576	80.70	gold quality
heart left ventricle	UBERON:0002084	75.19	gold quality
urinary bladder	UBERON:0001255	74.46	gold quality
left uterine tube	UBERON:0001303	73.67	gold quality
heart	UBERON:0000948	73.22	gold quality
myometrium	UBERON:0001296	72.66	gold quality
muscle of leg	UBERON:0001383	72.61	gold quality
gastrocnemius	UBERON:0001388	72.29	gold quality
body of uterus	UBERON:0009853	71.84	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.64	gold quality
blood	UBERON:0000178	71.58	gold quality
right atrium auricular region	UBERON:0006631	71.29	gold quality
endocervix	UBERON:0000458	70.61	gold quality
right ovary	UBERON:0002118	70.46	gold quality
body of stomach	UBERON:0001161	69.89	gold quality
fundus of stomach	UBERON:0001160	69.74	gold quality
descending thoracic aorta	UBERON:0002345	69.68	gold quality
subcutaneous adipose tissue	UBERON:0002190	69.63	gold quality
ectocervix	UBERON:0012249	69.62	gold quality
adipose tissue	UBERON:0001013	69.46	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.22	gold quality
omental fat pad	UBERON:0010414	69.04	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.83	gold quality
lower esophagus	UBERON:0013473	68.82	gold quality
putamen	UBERON:0001874	68.64	gold quality
tibial artery	UBERON:0007610	67.72	gold quality
ascending aorta	UBERON:0001496	67.65	gold quality
thoracic aorta	UBERON:0001515	67.62	gold quality
esophagus	UBERON:0001043	67.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.13

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.