MIR6724-3

Summary

MIR6724-3 (microRNA 6724-3, HGNC:50842) is a microRNA gene on chromosome 21p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 103504739 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50842
Approved symbol	MIR6724-3
Name	microRNA 6724-3
Location	21p11.2
Locus type	RNA, micro
Status	Approved
Ensembl gene	ENSG00000277379
Ensembl biotype	miRNA
Entrez	103504739
RNAcentral	URS00007B0327 — ncRNA, 92 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622482

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622482 — 1 exons

Exon	Start	End
ENSE00003717492	8388362	8388453

Expression profiles

Bgee: expression breadth broad, 95 present calls, max score 90.08.

Top tissues by expression

95 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	90.08	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.56	gold quality
monocyte	CL:0000576	79.71	gold quality
calcaneal tendon	UBERON:0003701	73.54	gold quality
skeletal muscle tissue	UBERON:0001134	73.03	gold quality
liver	UBERON:0002107	72.29	gold quality
blood	UBERON:0000178	71.27	gold quality
right lobe of liver	UBERON:0001114	69.79	gold quality
muscle of leg	UBERON:0001383	66.22	gold quality
lower esophagus mucosa	UBERON:0035834	66.20	gold quality
gastrocnemius	UBERON:0001388	65.12	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	64.98	gold quality
mucosa of stomach	UBERON:0001199	63.33	gold quality
endometrium	UBERON:0001295	63.25	gold quality
left uterine tube	UBERON:0001303	62.80	gold quality
granulocyte	CL:0000094	62.75	gold quality
right coronary artery	UBERON:0001625	62.07	gold quality
endocervix	UBERON:0000458	60.98	gold quality
right uterine tube	UBERON:0001302	60.78	gold quality
heart left ventricle	UBERON:0002084	60.72	gold quality
stomach	UBERON:0000945	60.64	gold quality
omental fat pad	UBERON:0010414	60.29	gold quality
descending thoracic aorta	UBERON:0002345	60.14	gold quality
heart	UBERON:0000948	60.13	gold quality
body of stomach	UBERON:0001161	59.94	gold quality
left ovary	UBERON:0002119	59.91	gold quality
apex of heart	UBERON:0002098	59.49	gold quality
transverse colon	UBERON:0001157	59.44	gold quality
right atrium auricular region	UBERON:0006631	59.13	gold quality
left coronary artery	UBERON:0001626	59.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (3): MIR6724-2 (ENSG00000274060), MIR6724-4 (ENSG00000275692), MIR6724-1 (ENSG00000275950)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.