MIR6726

Summary

MIR6726 (microRNA 6726, HGNC:50009) is a microRNA gene on chromosome 1p36.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465434 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50009
Approved symbol	MIR6726
Name	microRNA 6726
Location	1p36.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6726
Ensembl gene	ENSG00000278073
Ensembl biotype	miRNA
Entrez	102465434
RNAcentral	URS000075AD5C — miRNA, 61 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000613751

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000613751 — 1 exons

Exon	Start	End
ENSE00003729583	1296110	1296170

Expression profiles

Bgee: expression breadth broad, 67 present calls, max score 75.39.

Top tissues by expression

67 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
fundus of stomach	UBERON:0001160	75.39	gold quality
blood	UBERON:0000178	74.93	gold quality
right atrium auricular region	UBERON:0006631	72.43	gold quality
muscle of leg	UBERON:0001383	72.11	gold quality
gastrocnemius	UBERON:0001388	70.92	gold quality
ascending aorta	UBERON:0001496	70.60	gold quality
heart left ventricle	UBERON:0002084	70.46	gold quality
heart	UBERON:0000948	70.40	gold quality
thoracic aorta	UBERON:0001515	69.74	gold quality
stomach	UBERON:0000945	69.37	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.86	gold quality
body of stomach	UBERON:0001161	68.57	gold quality
tibial artery	UBERON:0007610	68.51	gold quality
cerebellar hemisphere	UBERON:0002245	68.28	gold quality
right hemisphere of cerebellum	UBERON:0014890	68.02	gold quality
omental fat pad	UBERON:0010414	68.00	gold quality
skin of abdomen	UBERON:0001416	67.70	gold quality
putamen	UBERON:0001874	67.59	gold quality
caudate nucleus	UBERON:0001873	67.35	gold quality
skin of leg	UBERON:0001511	67.20	gold quality
liver	UBERON:0002107	67.14	gold quality
transverse colon	UBERON:0001157	67.11	gold quality
cerebral cortex	UBERON:0000956	67.02	gold quality
brain	UBERON:0000955	66.99	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.98	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.93	gold quality
lower esophagus	UBERON:0013473	66.91	gold quality
anterior cingulate cortex	UBERON:0009835	66.86	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.85	gold quality
right frontal lobe	UBERON:0002810	66.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.