MIR6727

Summary

MIR6727 (microRNA 6727, HGNC:50171) is a microRNA gene on chromosome 1p36.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465435 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50171
Approved symbol	MIR6727
Name	microRNA 6727
Location	1p36.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6727
Ensembl gene	ENSG00000283712
Ensembl biotype	miRNA
Entrez	102465435
RNAcentral	URS000075E15F — miRNA, 65 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620702

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620702 — 1 exons

Exon	Start	End
ENSE00003723902	1312502	1312566

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 82.39.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	82.39	gold quality
prefrontal cortex	UBERON:0000451	75.34	gold quality
gastrocnemius	UBERON:0001388	71.15	gold quality
rectum	UBERON:0001052	70.61	gold quality
blood	UBERON:0000178	69.38	gold quality
tibial artery	UBERON:0007610	59.88	gold quality
skin of leg	UBERON:0001511	55.76	gold quality
right atrium auricular region	UBERON:0006631	52.72	gold quality
heart left ventricle	UBERON:0002084	51.45	gold quality
ascending aorta	UBERON:0001496	51.39	gold quality
body of pancreas	UBERON:0001150	40.01	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• T-box transcription factor TBX1, targeted by microRNA-6727-5p, inhibits cell growth and enhances cisplatin chemosensitivity of cervical cancer cells through AKT and MAPK pathways. (PMID:33557670)
• Extracellular microRNA profiling for prognostic prediction in patients with high-grade serous ovarian carcinoma. (PMID:34618992)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.