MIR6728

Summary

MIR6728 (microRNA 6728, HGNC:49961) is a microRNA gene on chromosome 1p36.23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465436 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49961
Approved symbol	MIR6728
Name	microRNA 6728
Location	1p36.23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6728
Ensembl gene	ENSG00000274258
Ensembl biotype	miRNA
Entrez	102465436
RNAcentral	URS000075D08A — miRNA, 89 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000618792

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618792 — 1 exons

Exon	Start	End
ENSE00003741900	8866502	8866590

Expression profiles

Bgee: expression breadth broad, 99 present calls, max score 81.56.

Top tissues by expression

99 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	81.56	gold quality
vermiform appendix	UBERON:0001154	79.97	gold quality
blood	UBERON:0000178	77.75	gold quality
adrenal tissue	UBERON:0018303	76.52	gold quality
monocyte	CL:0000576	76.23	gold quality
tonsil	UBERON:0002372	75.71	gold quality
lower esophagus mucosa	UBERON:0035834	75.24	gold quality
liver	UBERON:0002107	74.94	gold quality
gastrocnemius	UBERON:0001388	73.52	gold quality
granulocyte	CL:0000094	73.41	gold quality
islet of Langerhans	UBERON:0000006	73.34	gold quality
right lobe of liver	UBERON:0001114	72.59	gold quality
prefrontal cortex	UBERON:0000451	72.18	gold quality
esophagus mucosa	UBERON:0002469	71.83	gold quality
endometrium	UBERON:0001295	71.59	gold quality
right atrium auricular region	UBERON:0006631	71.40	gold quality
ascending aorta	UBERON:0001496	71.35	gold quality
rectum	UBERON:0001052	71.34	gold quality
esophagus	UBERON:0001043	71.15	gold quality
thoracic aorta	UBERON:0001515	70.93	gold quality
tibial artery	UBERON:0007610	70.87	gold quality
adrenal gland	UBERON:0002369	70.78	gold quality
body of stomach	UBERON:0001161	70.72	gold quality
heart	UBERON:0000948	70.68	gold quality
left adrenal gland	UBERON:0001234	70.67	gold quality
mucosa of transverse colon	UBERON:0004991	70.57	gold quality
stomach	UBERON:0000945	70.42	gold quality
vagina	UBERON:0000996	70.27	gold quality
saliva-secreting gland	UBERON:0001044	70.01	gold quality
omental fat pad	UBERON:0010414	69.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.