MIR6730

Summary

MIR6730 (microRNA 6730, HGNC:50222) is a microRNA gene on chromosome 1p36.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466722 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50222
Approved symbol	MIR6730
Name	microRNA 6730
Location	1p36.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6730
Ensembl gene	ENSG00000276830
Ensembl biotype	miRNA
Entrez	102466722
RNAcentral	URS00007E4D78 — miRNA, 67 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622213

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622213 — 1 exons

Exon	Start	End
ENSE00003726375	12578957	12579023

Expression profiles

Bgee: expression breadth ubiquitous, 108 present calls, max score 88.35.

Top tissues by expression

108 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	88.35	gold quality
lower esophagus mucosa	UBERON:0035834	85.98	gold quality
duodenum	UBERON:0002114	85.41	gold quality
sural nerve	UBERON:0015488	84.78	gold quality
tibial nerve	UBERON:0001323	84.68	gold quality
liver	UBERON:0002107	84.61	gold quality
prostate gland	UBERON:0002367	84.61	gold quality
right lobe of liver	UBERON:0001114	84.53	gold quality
ectocervix	UBERON:0012249	82.21	gold quality
vagina	UBERON:0000996	82.05	gold quality
right lobe of thyroid gland	UBERON:0001119	82.05	gold quality
smooth muscle tissue	UBERON:0001135	81.82	gold quality
thoracic mammary gland	UBERON:0005200	81.45	gold quality
prefrontal cortex	UBERON:0000451	81.07	gold quality
endocervix	UBERON:0000458	80.94	gold quality
left lobe of thyroid gland	UBERON:0001120	80.93	gold quality
thyroid gland	UBERON:0002046	80.67	gold quality
subcutaneous adipose tissue	UBERON:0002190	80.61	gold quality
urinary bladder	UBERON:0001255	80.54	gold quality
adipose tissue	UBERON:0001013	80.14	gold quality
endometrium	UBERON:0001295	80.00	gold quality
bone marrow	UBERON:0002371	79.86	gold quality
esophagus mucosa	UBERON:0002469	79.73	gold quality
placenta	UBERON:0001987	79.61	gold quality
monocyte	CL:0000576	79.59	gold quality
blood	UBERON:0000178	79.59	gold quality
omental fat pad	UBERON:0010414	79.58	gold quality
esophagus	UBERON:0001043	79.08	gold quality
adrenal tissue	UBERON:0018303	78.79	gold quality
muscle of leg	UBERON:0001383	78.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MicroRNA signature predicts survival in papillary thyroid carcinoma. (PMID:31099134)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.