MIR6731

Summary

MIR6731 (microRNA 6731, HGNC:50036) is a microRNA gene on chromosome 1p36.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465437 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50036
Approved symbol	MIR6731
Name	microRNA 6731
Location	1p36.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6731
Ensembl gene	ENSG00000278034
Ensembl biotype	miRNA
Entrez	102465437
RNAcentral	URS000075A557 — ncRNA, 72 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000614863

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000614863 — 1 exons

Exon	Start	End
ENSE00003727057	24919345	24919416

Expression profiles

Bgee: expression breadth broad, 47 present calls, max score 79.86.

Top tissues by expression

47 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	79.86	gold quality
bone marrow	UBERON:0002371	79.32	gold quality
myometrium	UBERON:0001296	78.83	gold quality
liver	UBERON:0002107	78.40	gold quality
granulocyte	CL:0000094	75.20	gold quality
monocyte	CL:0000576	75.09	gold quality
right frontal lobe	UBERON:0002810	71.86	gold quality
hypothalamus	UBERON:0001898	71.52	gold quality
body of stomach	UBERON:0001161	70.33	gold quality
multicellular organism	UBERON:0000468	69.76	gold quality
endometrium	UBERON:0001295	69.62	gold quality
right atrium auricular region	UBERON:0006631	68.98	gold quality
tibial artery	UBERON:0007610	68.77	gold quality
endocervix	UBERON:0000458	67.71	gold quality
stomach	UBERON:0000945	66.53	gold quality
putamen	UBERON:0001874	66.49	gold quality
skin of abdomen	UBERON:0001416	65.70	gold quality
thoracic aorta	UBERON:0001515	65.68	gold quality
skin of leg	UBERON:0001511	65.54	gold quality
ascending aorta	UBERON:0001496	65.18	gold quality
right ovary	UBERON:0002118	65.10	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.93	gold quality
spleen	UBERON:0002106	64.21	gold quality
omental fat pad	UBERON:0010414	64.21	gold quality
pituitary gland	UBERON:0000007	64.13	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.12	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.07	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.83	gold quality
vagina	UBERON:0000996	63.79	gold quality
transverse colon	UBERON:0001157	63.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.18

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.