MIR6732

Summary

MIR6732 (microRNA 6732, HGNC:50066) is a microRNA gene on chromosome 1p34.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465438 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50066
Approved symbol	MIR6732
Name	microRNA 6732
Location	1p34.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6732
Ensembl gene	ENSG00000283724
Ensembl biotype	miRNA
Entrez	102465438
RNAcentral	URS000075DED0 — ncRNA, 60 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619365

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619365 — 1 exons

Exon	Start	End
ENSE00003733616	37480230	37480289

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 80.37.

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.37	gold quality
adrenal tissue	UBERON:0018303	71.72	gold quality
gastrocnemius	UBERON:0001388	69.84	gold quality
heart left ventricle	UBERON:0002084	66.67	gold quality
body of pancreas	UBERON:0001150	61.41	gold quality
left lobe of thyroid gland	UBERON:0001120	58.79	gold quality
right hemisphere of cerebellum	UBERON:0014890	58.37	gold quality
cerebellar hemisphere	UBERON:0002245	56.16	gold quality
subcutaneous adipose tissue	UBERON:0002190	56.12	gold quality
right atrium auricular region	UBERON:0006631	56.10	gold quality
lower esophagus muscularis layer	UBERON:0035833	56.03	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	54.13	gold quality
body of stomach	UBERON:0001161	49.16	gold quality
upper lobe of left lung	UBERON:0008952	45.34	gold quality
omental fat pad	UBERON:0010414	45.32	gold quality
left testis	UBERON:0004533	25.73	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• HOXB5 promotes malignant progression in pancreatic cancer via the miR-6732 pathway. (PMID:31876226)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.