MIR6733

Summary

MIR6733 (microRNA 6733, HGNC:50239) is a microRNA gene on chromosome 1p34.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465439 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50239
Approved symbol	MIR6733
Name	microRNA 6733
Location	1p34.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6733
Ensembl gene	ENSG00000284410
Ensembl biotype	miRNA
Entrez	102465439
RNAcentral	URS000075BF12 — ncRNA, 61 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000635723

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000635723 — 1 exons

Exon	Start	End
ENSE00003800140	43171652	43171712

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 76.02.

Top tissues by expression

18 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	76.02	gold quality
body of stomach	UBERON:0001161	72.89	gold quality
tibial nerve	UBERON:0001323	65.94	gold quality
skin of abdomen	UBERON:0001416	64.24	gold quality
esophagus mucosa	UBERON:0002469	62.98	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.29	gold quality
anterior cingulate cortex	UBERON:0009835	61.74	gold quality
left lobe of thyroid gland	UBERON:0001120	59.48	gold quality
cerebellar hemisphere	UBERON:0002245	57.43	gold quality
adenohypophysis	UBERON:0002196	55.46	gold quality
right hemisphere of cerebellum	UBERON:0014890	54.04	gold quality
nucleus accumbens	UBERON:0001882	52.98	gold quality
right frontal lobe	UBERON:0002810	52.93	gold quality
putamen	UBERON:0001874	51.73	gold quality
thyroid gland	UBERON:0002046	51.00	gold quality
prostate gland	UBERON:0002367	45.69	gold quality
vagina	UBERON:0000996	44.98	gold quality
left testis	UBERON:0004533	32.00	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.