MIR6734

Summary

MIR6734 (microRNA 6734, HGNC:50219) is a microRNA gene on chromosome 1p34.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466723 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50219
Approved symbol	MIR6734
Name	microRNA 6734
Location	1p34.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6734
Ensembl gene	ENSG00000283836
Ensembl biotype	miRNA
Entrez	102466723
RNAcentral	URS000075C67C — ncRNA, 68 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000621166

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000621166 — 1 exons

Exon	Start	End
ENSE00003727078	43364648	43364715

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 73.34.

Top tissues by expression

17 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	73.34	gold quality
gastrocnemius	UBERON:0001388	65.94	gold quality
heart left ventricle	UBERON:0002084	65.23	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.88	gold quality
right atrium auricular region	UBERON:0006631	64.48	gold quality
hypothalamus	UBERON:0001898	62.28	gold quality
multicellular organism	UBERON:0000468	61.77	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.20	gold quality
omental fat pad	UBERON:0010414	60.73	gold quality
Ammon’s horn	UBERON:0001954	57.70	gold quality
putamen	UBERON:0001874	57.06	gold quality
brain	UBERON:0000955	56.12	gold quality
ascending aorta	UBERON:0001496	54.78	gold quality
tibial artery	UBERON:0007610	52.09	gold quality
right lobe of liver	UBERON:0001114	51.35	silver quality
caudate nucleus	UBERON:0001873	40.06	silver quality
left testis	UBERON:0004533	32.58	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• MiR-6734 inhibits the growth of colon cancer cells by up-regulating p21 gene expression and subsequent induction of cell cycle arrest and apoptosis. (PMID:27509128)
• Targeting the miR-6734-3p/ZEB2 axis hampers development of non-small cell lung cancer (NSCLC) and increases susceptibility of cancer cells to cisplatin treatment. (PMID:34107856)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.