MIR6735

Summary

MIR6735 (microRNA 6735, HGNC:50126) is a microRNA gene on chromosome 1p34.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465440 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50126
Approved symbol	MIR6735
Name	microRNA 6735
Location	1p34.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6735
Ensembl gene	ENSG00000274975
Ensembl biotype	miRNA
Entrez	102465440
RNAcentral	URS000075ED0C — miRNA, 73 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000615179

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000615179 — 1 exons

Exon	Start	End
ENSE00003732967	43448539	43448611

Expression profiles

Bgee: expression breadth broad, 28 present calls, max score 71.70.

Top tissues by expression

28 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart left ventricle	UBERON:0002084	71.70	gold quality
liver	UBERON:0002107	68.93	gold quality
skin of leg	UBERON:0001511	66.08	gold quality
tibial artery	UBERON:0007610	65.23	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.86	gold quality
thoracic mammary gland	UBERON:0005200	64.83	gold quality
left coronary artery	UBERON:0001626	63.92	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.66	gold quality
myometrium	UBERON:0001296	62.21	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.97	gold quality
endocervix	UBERON:0000458	61.28	gold quality
Ammon’s horn	UBERON:0001954	60.84	gold quality
skin of abdomen	UBERON:0001416	60.65	gold quality
nucleus accumbens	UBERON:0001882	60.65	gold quality
ascending aorta	UBERON:0001496	59.83	gold quality
lower esophagus muscularis layer	UBERON:0035833	58.85	gold quality
esophagus mucosa	UBERON:0002469	57.64	gold quality
adenohypophysis	UBERON:0002196	57.63	gold quality
omental fat pad	UBERON:0010414	56.67	gold quality
cerebellar hemisphere	UBERON:0002245	54.97	gold quality
left lobe of thyroid gland	UBERON:0001120	54.74	gold quality
transverse colon	UBERON:0001157	53.97	gold quality
right hemisphere of cerebellum	UBERON:0014890	52.43	gold quality
muscle layer of sigmoid colon	UBERON:0035805	51.94	gold quality
spleen	UBERON:0002106	48.72	gold quality
pituitary gland	UBERON:0000007	47.54	gold quality
left ovary	UBERON:0002119	44.37	silver quality
left testis	UBERON:0004533	42.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.