MIR6736

Summary

MIR6736 (microRNA 6736, HGNC:50072) is a microRNA gene on chromosome 1q21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466191 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50072
Approved symbol	MIR6736
Name	microRNA 6736
Location	1q21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6736
Ensembl gene	ENSG00000278549
Ensembl biotype	miRNA
Entrez	102466191
RNAcentral	URS000075E9A6 — ncRNA, 59 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000616799

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000616799 — 1 exons

Exon	Start	End
ENSE00003747035	145850587	145850645

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 83.70.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	83.70	gold quality
right uterine tube	UBERON:0001302	80.36	gold quality
bone marrow	UBERON:0002371	79.24	gold quality
monocyte	CL:0000576	78.75	gold quality
prefrontal cortex	UBERON:0000451	78.74	gold quality
lymph node	UBERON:0000029	76.51	gold quality
blood	UBERON:0000178	75.49	gold quality
endocervix	UBERON:0000458	74.24	gold quality
fallopian tube	UBERON:0003889	73.94	gold quality
muscle of leg	UBERON:0001383	73.77	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.48	gold quality
gastrocnemius	UBERON:0001388	73.41	gold quality
minor salivary gland	UBERON:0001830	72.46	gold quality
body of stomach	UBERON:0001161	72.32	gold quality
urinary bladder	UBERON:0001255	72.30	gold quality
myometrium	UBERON:0001296	72.22	gold quality
descending thoracic aorta	UBERON:0002345	72.22	gold quality
stomach	UBERON:0000945	72.15	gold quality
tibial artery	UBERON:0007610	72.15	gold quality
endometrium	UBERON:0001295	71.92	gold quality
heart left ventricle	UBERON:0002084	71.80	gold quality
rectum	UBERON:0001052	71.64	gold quality
body of pancreas	UBERON:0001150	71.32	gold quality
thoracic aorta	UBERON:0001515	71.23	gold quality
ascending aorta	UBERON:0001496	71.11	gold quality
body of uterus	UBERON:0009853	71.10	gold quality
right lobe of liver	UBERON:0001114	71.08	gold quality
esophagus mucosa	UBERON:0002469	70.79	gold quality
heart	UBERON:0000948	70.75	gold quality
islet of Langerhans	UBERON:0000006	70.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long noncoding RNA RP11-70C1.3 confers chemoresistance of breast cancer cells through miR-6736-3p/NRP-1 axis. (PMID:34374639)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.