MIR6737

Summary

MIR6737 (microRNA 6737, HGNC:50273) is a microRNA gene on chromosome 1q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465441 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50273
Approved symbol	MIR6737
Name	microRNA 6737
Location	1q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6737
Ensembl gene	ENSG00000276584
Ensembl biotype	miRNA
Entrez	102465441
RNAcentral	URS000075AF9B — ncRNA, 70 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617385

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617385 — 1 exons

Exon	Start	End
ENSE00003751877	153962351	153962420

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 79.17.

Top tissues by expression

55 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	79.17	gold quality
myometrium	UBERON:0001296	78.57	gold quality
adrenal tissue	UBERON:0018303	77.12	gold quality
blood	UBERON:0000178	73.30	gold quality
granulocyte	CL:0000094	71.93	gold quality
islet of Langerhans	UBERON:0000006	71.20	gold quality
gastrocnemius	UBERON:0001388	70.91	gold quality
ectocervix	UBERON:0012249	70.87	gold quality
tonsil	UBERON:0002372	70.79	gold quality
heart left ventricle	UBERON:0002084	69.91	gold quality
urinary bladder	UBERON:0001255	69.74	gold quality
endometrium	UBERON:0001295	69.18	gold quality
body of stomach	UBERON:0001161	68.01	gold quality
tibial artery	UBERON:0007610	67.39	gold quality
gall bladder	UBERON:0002110	67.29	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.27	gold quality
body of uterus	UBERON:0009853	67.16	gold quality
skin of leg	UBERON:0001511	66.98	gold quality
right atrium auricular region	UBERON:0006631	66.90	gold quality
esophagus	UBERON:0001043	66.54	gold quality
transverse colon	UBERON:0001157	65.79	gold quality
left coronary artery	UBERON:0001626	65.75	gold quality
amygdala	UBERON:0001876	65.60	gold quality
right adrenal gland cortex	UBERON:0035827	64.89	gold quality
omental fat pad	UBERON:0010414	64.87	gold quality
left ovary	UBERON:0002119	64.68	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.49	gold quality
esophagus mucosa	UBERON:0002469	64.28	gold quality
Ammon’s horn	UBERON:0001954	64.20	gold quality
left adrenal gland	UBERON:0001234	63.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.12

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.