MIR6738

Summary

MIR6738 (microRNA 6738, HGNC:49939) is a microRNA gene on chromosome 1q22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465442 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49939
Approved symbol	MIR6738
Name	microRNA 6738
Location	1q22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6738
Ensembl gene	ENSG00000277817
Ensembl biotype	miRNA
Entrez	102465442
RNAcentral	URS0000759AAA — ncRNA, 64 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619620

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619620 — 1 exons

Exon	Start	End
ENSE00003715528	155951273	155951336

Expression profiles

Bgee: expression breadth broad, 75 present calls, max score 89.69.

Top tissues by expression

75 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	89.69	gold quality
vermiform appendix	UBERON:0001154	85.77	gold quality
prefrontal cortex	UBERON:0000451	83.54	gold quality
kidney	UBERON:0002113	80.99	gold quality
blood	UBERON:0000178	78.45	gold quality
left adrenal gland	UBERON:0001234	75.64	gold quality
monocyte	CL:0000576	75.41	gold quality
gastrocnemius	UBERON:0001388	73.73	gold quality
granulocyte	CL:0000094	73.08	gold quality
putamen	UBERON:0001874	73.05	gold quality
liver	UBERON:0002107	72.94	gold quality
right adrenal gland cortex	UBERON:0035827	72.76	gold quality
right lobe of liver	UBERON:0001114	72.43	gold quality
stomach	UBERON:0000945	71.28	gold quality
ectocervix	UBERON:0012249	71.23	gold quality
islet of Langerhans	UBERON:0000006	70.94	gold quality
body of stomach	UBERON:0001161	70.74	gold quality
heart	UBERON:0000948	70.35	gold quality
heart left ventricle	UBERON:0002084	70.13	gold quality
right frontal lobe	UBERON:0002810	70.01	gold quality
right atrium auricular region	UBERON:0006631	69.34	gold quality
tibial artery	UBERON:0007610	69.24	gold quality
body of pancreas	UBERON:0001150	69.06	gold quality
thoracic aorta	UBERON:0001515	68.48	gold quality
ascending aorta	UBERON:0001496	68.31	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.67	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.61	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.83	gold quality
descending thoracic aorta	UBERON:0002345	66.74	gold quality
omental fat pad	UBERON:0010414	66.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.07

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.