MIR6739

Summary

MIR6739 (microRNA 6739, HGNC:50165) is a microRNA gene on chromosome 1q32.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466724 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50165
Approved symbol	MIR6739
Name	microRNA 6739
Location	1q32.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6739
Ensembl gene	ENSG00000277681
Ensembl biotype	miRNA
Entrez	102466724
RNAcentral	URS000075B174 — ncRNA, 75 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622461

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622461 — 1 exons

Exon	Start	End
ENSE00003726661	201863373	201863447

Expression profiles

Bgee: expression breadth broad, 91 present calls, max score 82.24.

Top tissues by expression

91 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	82.24	gold quality
adrenal tissue	UBERON:0018303	79.12	gold quality
endometrium	UBERON:0001295	78.80	gold quality
bone marrow	UBERON:0002371	77.67	gold quality
lymph node	UBERON:0000029	77.08	gold quality
sural nerve	UBERON:0015488	77.04	gold quality
prefrontal cortex	UBERON:0000451	76.22	gold quality
muscle of leg	UBERON:0001383	74.50	gold quality
blood	UBERON:0000178	74.30	gold quality
liver	UBERON:0002107	74.02	gold quality
monocyte	CL:0000576	72.39	gold quality
gastrocnemius	UBERON:0001388	72.17	gold quality
islet of Langerhans	UBERON:0000006	71.09	gold quality
heart left ventricle	UBERON:0002084	70.65	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.54	gold quality
heart	UBERON:0000948	69.41	gold quality
stomach	UBERON:0000945	69.01	gold quality
body of stomach	UBERON:0001161	68.78	gold quality
body of pancreas	UBERON:0001150	68.72	gold quality
rectum	UBERON:0001052	68.70	gold quality
kidney	UBERON:0002113	68.09	gold quality
lung	UBERON:0002048	68.05	gold quality
adenohypophysis	UBERON:0002196	68.05	gold quality
adrenal gland	UBERON:0002369	67.70	gold quality
anterior cingulate cortex	UBERON:0009835	67.42	gold quality
tibial artery	UBERON:0007610	67.40	gold quality
right adrenal gland cortex	UBERON:0035827	67.36	gold quality
caudate nucleus	UBERON:0001873	67.11	gold quality
right lobe of liver	UBERON:0001114	67.03	gold quality
left adrenal gland cortex	UBERON:0035825	66.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.21

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.