MIR6740

Summary

MIR6740 (microRNA 6740, HGNC:50082) is a microRNA gene on chromosome 1q32.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465443 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50082
Approved symbol	MIR6740
Name	microRNA 6740
Location	1q32.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6740
Ensembl gene	ENSG00000275207
Ensembl biotype	miRNA
Entrez	102465443
RNAcentral	URS000075D24A — ncRNA, 113 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000618268

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618268 — 1 exons

Exon	Start	End
ENSE00003737556	202003124	202003236

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 84.86.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	84.86	gold quality
adrenal tissue	UBERON:0018303	80.12	gold quality
granulocyte	CL:0000094	78.35	gold quality
monocyte	CL:0000576	75.17	gold quality
blood	UBERON:0000178	75.14	gold quality
placenta	UBERON:0001987	75.10	gold quality
duodenum	UBERON:0002114	75.02	gold quality
bone marrow	UBERON:0002371	74.92	gold quality
ectocervix	UBERON:0012249	73.32	gold quality
body of pancreas	UBERON:0001150	73.27	gold quality
islet of Langerhans	UBERON:0000006	73.04	gold quality
muscle of leg	UBERON:0001383	72.87	gold quality
endometrium	UBERON:0001295	72.67	gold quality
lymph node	UBERON:0000029	72.44	gold quality
stomach	UBERON:0000945	72.44	gold quality
gastrocnemius	UBERON:0001388	72.22	gold quality
adult mammalian kidney	UBERON:0000082	72.11	gold quality
body of stomach	UBERON:0001161	72.01	gold quality
heart left ventricle	UBERON:0002084	71.76	gold quality
transverse colon	UBERON:0001157	71.74	gold quality
esophagus mucosa	UBERON:0002469	71.38	gold quality
liver	UBERON:0002107	71.04	gold quality
right lobe of liver	UBERON:0001114	70.88	gold quality
intestine	UBERON:0000160	70.71	gold quality
tonsil	UBERON:0002372	70.67	gold quality
colon	UBERON:0001155	70.65	gold quality
body of uterus	UBERON:0009853	70.61	gold quality
small intestine	UBERON:0002108	70.60	gold quality
esophagus	UBERON:0001043	70.43	gold quality
left lobe of thyroid gland	UBERON:0001120	70.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.70

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.