MIR6741

Summary

MIR6741 (microRNA 6741, HGNC:50004) is a microRNA gene on chromosome 1q42.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466270 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50004
Approved symbol	MIR6741
Name	microRNA 6741
Location	1q42.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6741
Ensembl gene	ENSG00000284519
Ensembl biotype	miRNA
Entrez	102466270
RNAcentral	URS000075A701 — ncRNA, 63 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000618782

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618782 — 1 exons

Exon	Start	End
ENSE00003733914	225922080	225922142

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 76.03.

Top tissues by expression

5 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	76.03	gold quality
gastrocnemius	UBERON:0001388	65.66	gold quality
omental fat pad	UBERON:0010414	65.49	gold quality
caudate nucleus	UBERON:0001873	59.64	gold quality
skin of leg	UBERON:0001511	40.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• SNPs at 3’UTR of APOL1 and miR-6741-3p target sites associated with kidney diseases more susceptible to SARS-COV-2 infection: in silco and in vitro studies. (PMID:34089082)
• Intronic miR-6741-3p targets the oncogene SRSF3: Implications for oral squamous cell carcinoma pathogenesis. (PMID:38781195)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.