MIR6742

Summary

MIR6742 (microRNA 6742, HGNC:50090) is a microRNA gene on chromosome 1q42.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465444 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50090
Approved symbol	MIR6742
Name	microRNA 6742
Location	1q42.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6742
Ensembl gene	ENSG00000284311
Ensembl biotype	miRNA
Entrez	102465444
RNAcentral	URS000075A66D — miRNA, 62 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622338

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622338 — 1 exons

Exon	Start	End
ENSE00003738798	228397048	228397109

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 75.65.

Top tissues by expression

10 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	75.65	gold quality
cerebellar hemisphere	UBERON:0002245	64.97	gold quality
esophagus mucosa	UBERON:0002469	62.10	gold quality
tibial nerve	UBERON:0001323	61.83	gold quality
spleen	UBERON:0002106	61.34	gold quality
omental fat pad	UBERON:0010414	60.97	gold quality
pituitary gland	UBERON:0000007	60.41	gold quality
lung	UBERON:0002048	59.39	gold quality
subcutaneous adipose tissue	UBERON:0002190	57.53	gold quality
left testis	UBERON:0004533	43.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-6742-5p regulates the invasion and migration of lung adenocarcinoma cells via mediating FGF8/ERK12/MMP9/MMP2 signaling pathway. (PMID:36629518)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.