MIR6744

Summary

MIR6744 (microRNA 6744, HGNC:50051) is a microRNA gene on chromosome 11p15.5.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466725 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50051
Approved symbol	MIR6744
Name	microRNA 6744
Location	11p15.5
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6744
Ensembl gene	ENSG00000275669
Ensembl biotype	miRNA
Entrez	102466725
RNAcentral	URS0000759A42 — miRNA, 66 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619480

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619480 — 1 exons

Exon	Start	End
ENSE00003718611	1256605	1256670

Expression profiles

Bgee: expression breadth broad, 47 present calls, max score 91.46.

Top tissues by expression

47 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	91.46	gold quality
minor salivary gland	UBERON:0001830	79.87	gold quality
saliva-secreting gland	UBERON:0001044	79.81	gold quality
endocervix	UBERON:0000458	79.00	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	75.42	gold quality
gastrocnemius	UBERON:0001388	75.09	gold quality
blood	UBERON:0000178	74.79	gold quality
endometrium	UBERON:0001295	72.02	gold quality
gall bladder	UBERON:0002110	71.60	gold quality
upper lobe of left lung	UBERON:0008952	70.92	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.85	gold quality
stomach	UBERON:0000945	70.35	gold quality
body of uterus	UBERON:0009853	69.93	gold quality
transverse colon	UBERON:0001157	69.69	gold quality
colon	UBERON:0001155	69.33	gold quality
esophagus	UBERON:0001043	68.97	gold quality
right atrium auricular region	UBERON:0006631	68.92	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.56	gold quality
body of pancreas	UBERON:0001150	68.51	gold quality
cerebellar hemisphere	UBERON:0002245	68.40	gold quality
esophagus mucosa	UBERON:0002469	68.34	gold quality
caudate nucleus	UBERON:0001873	67.92	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.63	gold quality
thoracic mammary gland	UBERON:0005200	67.33	gold quality
body of stomach	UBERON:0001161	67.09	gold quality
left uterine tube	UBERON:0001303	67.03	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.59	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.24	gold quality
prostate gland	UBERON:0002367	65.77	gold quality
mucosa of transverse colon	UBERON:0004991	65.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MicroRNA-6744-5p promotes anoikis in breast cancer and directly targets NAT1 enzyme. (PMID:32296579)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.