MIR6745

Summary

MIR6745 (microRNA 6745, HGNC:50106) is a microRNA gene on chromosome 11p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466726 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50106
Approved symbol	MIR6745
Name	microRNA 6745
Location	11p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6745
Ensembl gene	ENSG00000275208
Ensembl biotype	miRNA
Entrez	102466726
RNAcentral	URS000075C2C8 — ncRNA, 127 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612694

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612694 — 1 exons

Exon	Start	End
ENSE00003722038	47179611	47179737

Expression profiles

Bgee: expression breadth broad, 93 present calls, max score 84.48.

Top tissues by expression

93 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	84.48	gold quality
lower esophagus mucosa	UBERON:0035834	79.50	gold quality
skeletal muscle tissue	UBERON:0001134	79.47	gold quality
heart left ventricle	UBERON:0002084	77.53	gold quality
apex of heart	UBERON:0002098	76.80	gold quality
muscle of leg	UBERON:0001383	76.76	gold quality
gastrocnemius	UBERON:0001388	76.10	gold quality
right adrenal gland cortex	UBERON:0035827	75.91	gold quality
liver	UBERON:0002107	75.36	gold quality
heart	UBERON:0000948	75.24	gold quality
right lobe of liver	UBERON:0001114	74.56	gold quality
left adrenal gland cortex	UBERON:0035825	73.93	gold quality
right atrium auricular region	UBERON:0006631	73.16	gold quality
left uterine tube	UBERON:0001303	72.45	gold quality
esophagus mucosa	UBERON:0002469	72.36	gold quality
body of pancreas	UBERON:0001150	72.29	gold quality
right adrenal gland	UBERON:0001233	72.27	gold quality
right coronary artery	UBERON:0001625	71.91	gold quality
adrenal gland	UBERON:0002369	71.86	gold quality
islet of Langerhans	UBERON:0000006	71.81	gold quality
left adrenal gland	UBERON:0001234	71.73	gold quality
placenta	UBERON:0001987	71.53	gold quality
blood	UBERON:0000178	71.27	gold quality
thoracic aorta	UBERON:0001515	71.17	gold quality
ascending aorta	UBERON:0001496	71.14	gold quality
descending thoracic aorta	UBERON:0002345	71.05	gold quality
esophagus	UBERON:0001043	70.72	gold quality
lymph node	UBERON:0000029	70.71	gold quality
saliva-secreting gland	UBERON:0001044	70.69	gold quality
minor salivary gland	UBERON:0001830	70.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.07

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-6745-TIMP1 axis inhibits cell growth and metastasis in gastric cancer. (PMID:34775375)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.