MIR6746

Summary

MIR6746 (microRNA 6746, HGNC:49925) is a microRNA gene on chromosome 11q12.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465446 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49925
Approved symbol	MIR6746
Name	microRNA 6746
Location	11q12.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6746
Ensembl gene	ENSG00000277892
Ensembl biotype	miRNA
Entrez	102465446
RNAcentral	URS000075D414 — ncRNA, 63 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620971

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620971 — 1 exons

Exon	Start	End
ENSE00003728226	61878216	61878278

Expression profiles

Bgee: expression breadth broad, 99 present calls, max score 88.98.

Top tissues by expression

99 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	88.98	gold quality
bone marrow	UBERON:0002371	85.59	gold quality
vermiform appendix	UBERON:0001154	84.45	gold quality
placenta	UBERON:0001987	82.79	gold quality
ascending aorta	UBERON:0001496	81.86	gold quality
tibial artery	UBERON:0007610	81.76	gold quality
popliteal artery	UBERON:0002250	81.74	gold quality
tibial nerve	UBERON:0001323	81.69	gold quality
thoracic aorta	UBERON:0001515	81.32	gold quality
subcutaneous adipose tissue	UBERON:0002190	81.21	gold quality
mucosa of stomach	UBERON:0001199	81.20	gold quality
adipose tissue	UBERON:0001013	80.87	gold quality
omental fat pad	UBERON:0010414	80.14	gold quality
muscle of leg	UBERON:0001383	79.98	gold quality
gastrocnemius	UBERON:0001388	79.58	gold quality
lymph node	UBERON:0000029	79.29	gold quality
prefrontal cortex	UBERON:0000451	78.43	gold quality
descending thoracic aorta	UBERON:0002345	78.35	gold quality
right atrium auricular region	UBERON:0006631	78.13	gold quality
heart	UBERON:0000948	77.43	gold quality
calcaneal tendon	UBERON:0003701	77.24	gold quality
heart left ventricle	UBERON:0002084	77.23	gold quality
thoracic mammary gland	UBERON:0005200	76.81	gold quality
left coronary artery	UBERON:0001626	76.79	gold quality
fundus of stomach	UBERON:0001160	76.18	gold quality
corpus callosum	UBERON:0002336	76.05	gold quality
metanephros cortex	UBERON:0010533	75.09	gold quality
ectocervix	UBERON:0012249	74.79	gold quality
blood	UBERON:0000178	74.39	gold quality
islet of Langerhans	UBERON:0000006	74.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.39

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.