MIR6747

Summary

MIR6747 (microRNA 6747, HGNC:50027) is a microRNA gene on chromosome 11q12.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465447 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50027
Approved symbol	MIR6747
Name	microRNA 6747
Location	11q12.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6747
Ensembl gene	ENSG00000276102
Ensembl biotype	miRNA
Entrez	102465447
RNAcentral	URS000075BE67 — ncRNA, 61 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617193

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617193 — 1 exons

Exon	Start	End
ENSE00003731630	62567011	62567071

Expression profiles

Bgee: expression breadth broad, 82 present calls, max score 80.24.

Top tissues by expression

82 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	80.24	gold quality
adrenal tissue	UBERON:0018303	79.29	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	78.44	gold quality
apex of heart	UBERON:0002098	77.74	gold quality
blood	UBERON:0000178	76.73	gold quality
right frontal lobe	UBERON:0002810	76.68	gold quality
monocyte	CL:0000576	75.97	gold quality
gastrocnemius	UBERON:0001388	75.07	gold quality
lymph node	UBERON:0000029	73.23	gold quality
smooth muscle tissue	UBERON:0001135	71.74	gold quality
heart	UBERON:0000948	71.59	gold quality
liver	UBERON:0002107	71.58	gold quality
rectum	UBERON:0001052	71.51	gold quality
body of pancreas	UBERON:0001150	71.43	gold quality
islet of Langerhans	UBERON:0000006	71.12	gold quality
right atrium auricular region	UBERON:0006631	70.99	gold quality
stomach	UBERON:0000945	70.94	gold quality
heart left ventricle	UBERON:0002084	70.91	gold quality
right adrenal gland cortex	UBERON:0035827	70.39	gold quality
tibial artery	UBERON:0007610	70.27	gold quality
kidney	UBERON:0002113	69.56	gold quality
skin of abdomen	UBERON:0001416	69.27	gold quality
substantia nigra	UBERON:0002038	69.17	gold quality
right lobe of liver	UBERON:0001114	69.15	gold quality
esophagus mucosa	UBERON:0002469	69.05	gold quality
left adrenal gland cortex	UBERON:0035825	69.04	gold quality
body of stomach	UBERON:0001161	69.02	gold quality
transverse colon	UBERON:0001157	68.88	gold quality
adrenal gland	UBERON:0002369	68.36	gold quality
ascending aorta	UBERON:0001496	68.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.