MIR6748

Summary

MIR6748 (microRNA 6748, HGNC:50141) is a microRNA gene on chromosome 11q12.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465448 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50141
Approved symbol	MIR6748
Name	microRNA 6748
Location	11q12.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6748
Ensembl gene	ENSG00000284535
Ensembl biotype	miRNA
Entrez	102465448
RNAcentral	URS000075D023 — miRNA, 71 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000610433

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000610433 — 1 exons

Exon	Start	End
ENSE00003725093	62789815	62789885

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 73.00.

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
nucleus accumbens	UBERON:0001882	73.00	gold quality
gastrocnemius	UBERON:0001388	70.76	gold quality
blood	UBERON:0000178	65.89	gold quality
amygdala	UBERON:0001876	64.21	gold quality
esophagus mucosa	UBERON:0002469	61.54	gold quality
heart left ventricle	UBERON:0002084	60.82	gold quality
subcutaneous adipose tissue	UBERON:0002190	60.64	gold quality
anterior cingulate cortex	UBERON:0009835	59.38	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	58.92	gold quality
adipose tissue	UBERON:0001013	57.79	gold quality
lower esophagus muscularis layer	UBERON:0035833	56.48	gold quality
caudate nucleus	UBERON:0001873	55.81	gold quality
stomach	UBERON:0000945	49.77	gold quality
skin of leg	UBERON:0001511	49.01	gold quality
hypothalamus	UBERON:0001898	43.65	silver quality
body of stomach	UBERON:0001161	41.79	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.