MIR6749

Summary

MIR6749 (microRNA 6749, HGNC:50087) is a microRNA gene on chromosome 11q13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466727 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50087
Approved symbol	MIR6749
Name	microRNA 6749
Location	11q13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6749
Ensembl gene	ENSG00000274314
Ensembl biotype	miRNA
Entrez	102466727
RNAcentral	URS000075E855 — miRNA, 69 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617008

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617008 — 1 exons

Exon	Start	End
ENSE00003733137	64902387	64902455

Expression profiles

Bgee: expression breadth broad, 80 present calls, max score 85.53.

Top tissues by expression

80 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	85.53	gold quality
vermiform appendix	UBERON:0001154	83.50	gold quality
blood	UBERON:0000178	79.99	gold quality
lymph node	UBERON:0000029	77.50	gold quality
monocyte	CL:0000576	77.42	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	76.57	gold quality
muscle of leg	UBERON:0001383	75.09	gold quality
amygdala	UBERON:0001876	74.80	gold quality
liver	UBERON:0002107	74.19	gold quality
gastrocnemius	UBERON:0001388	74.06	gold quality
granulocyte	CL:0000094	72.19	gold quality
right lobe of liver	UBERON:0001114	71.92	gold quality
prefrontal cortex	UBERON:0000451	71.53	gold quality
endometrium	UBERON:0001295	70.89	gold quality
heart left ventricle	UBERON:0002084	70.54	gold quality
body of stomach	UBERON:0001161	70.44	gold quality
right atrium auricular region	UBERON:0006631	70.10	gold quality
heart	UBERON:0000948	69.89	gold quality
stomach	UBERON:0000945	69.76	gold quality
body of pancreas	UBERON:0001150	69.05	gold quality
adrenal gland	UBERON:0002369	68.73	gold quality
left adrenal gland	UBERON:0001234	68.44	gold quality
substantia nigra	UBERON:0002038	68.00	gold quality
left adrenal gland cortex	UBERON:0035825	67.62	gold quality
thoracic aorta	UBERON:0001515	67.50	gold quality
right coronary artery	UBERON:0001625	67.37	gold quality
ascending aorta	UBERON:0001496	67.18	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.13	gold quality
body of uterus	UBERON:0009853	67.04	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.21

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.