MIR6750

Summary

MIR6750 (microRNA 6750, HGNC:49965) is a microRNA gene on chromosome 11q13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466192 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49965
Approved symbol	MIR6750
Name	microRNA 6750
Location	11q13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6750
Ensembl gene	ENSG00000274986
Ensembl biotype	miRNA
Entrez	102466192
RNAcentral	URS000075D4B7 — ncRNA, 75 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617817

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617817 — 1 exons

Exon	Start	End
ENSE00003748392	64898363	64898437

Expression profiles

Bgee: expression breadth ubiquitous, 104 present calls, max score 96.48.

Top tissues by expression

104 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	96.48	gold quality
duodenum	UBERON:0002114	90.27	gold quality
skeletal muscle tissue	UBERON:0001134	88.50	gold quality
blood	UBERON:0000178	84.68	gold quality
vermiform appendix	UBERON:0001154	84.13	gold quality
placenta	UBERON:0001987	77.97	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	77.70	gold quality
adrenal tissue	UBERON:0018303	76.17	gold quality
muscle of leg	UBERON:0001383	75.66	gold quality
tonsil	UBERON:0002372	75.63	gold quality
skin of leg	UBERON:0001511	75.46	gold quality
liver	UBERON:0002107	75.43	gold quality
islet of Langerhans	UBERON:0000006	75.34	gold quality
zone of skin	UBERON:0000014	75.11	gold quality
gastrocnemius	UBERON:0001388	74.85	gold quality
monocyte	CL:0000576	74.82	gold quality
skin of abdomen	UBERON:0001416	74.64	gold quality
endometrium	UBERON:0001295	74.09	gold quality
right lobe of liver	UBERON:0001114	73.23	gold quality
urinary bladder	UBERON:0001255	72.70	gold quality
body of stomach	UBERON:0001161	72.59	gold quality
right atrium auricular region	UBERON:0006631	72.44	gold quality
heart left ventricle	UBERON:0002084	72.32	gold quality
stomach	UBERON:0000945	72.28	gold quality
upper lobe of left lung	UBERON:0008952	72.24	gold quality
popliteal artery	UBERON:0002250	72.21	gold quality
tibial artery	UBERON:0007610	72.18	gold quality
ectocervix	UBERON:0012249	72.13	gold quality
lung	UBERON:0002048	72.03	gold quality
ascending aorta	UBERON:0001496	71.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.18

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.