MIR6751

Summary

MIR6751 (microRNA 6751, HGNC:49983) is a microRNA gene on chromosome 11q13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465449 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49983
Approved symbol	MIR6751
Name	microRNA 6751
Location	11q13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6751
Ensembl gene	ENSG00000284489
Ensembl biotype	miRNA
Entrez	102465449
RNAcentral	URS000075B59D — ncRNA, 63 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000610479

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000610479 — 1 exons

Exon	Start	End
ENSE00003734245	65129916	65129978

Expression profiles

Bgee: expression breadth broad, 45 present calls, max score 84.76.

Top tissues by expression

45 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	84.76	gold quality
liver	UBERON:0002107	79.15	gold quality
right atrium auricular region	UBERON:0006631	69.29	gold quality
stomach	UBERON:0000945	66.60	gold quality
blood	UBERON:0000178	66.59	gold quality
gastrocnemius	UBERON:0001388	66.55	gold quality
left coronary artery	UBERON:0001626	65.73	gold quality
body of stomach	UBERON:0001161	65.00	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.97	gold quality
body of pancreas	UBERON:0001150	64.94	gold quality
heart left ventricle	UBERON:0002084	64.29	gold quality
tibial artery	UBERON:0007610	63.09	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.73	gold quality
vagina	UBERON:0000996	60.99	gold quality
descending thoracic aorta	UBERON:0002345	60.65	gold quality
ascending aorta	UBERON:0001496	60.22	gold quality
muscle layer of sigmoid colon	UBERON:0035805	59.65	gold quality
colon	UBERON:0001155	58.40	gold quality
subcutaneous adipose tissue	UBERON:0002190	58.34	gold quality
caudate nucleus	UBERON:0001873	58.32	gold quality
esophagus mucosa	UBERON:0002469	58.10	gold quality
minor salivary gland	UBERON:0001830	58.08	gold quality
right lobe of thyroid gland	UBERON:0001119	56.89	gold quality
transverse colon	UBERON:0001157	56.07	gold quality
skin of leg	UBERON:0001511	55.98	gold quality
left ovary	UBERON:0002119	55.95	gold quality
skin of abdomen	UBERON:0001416	55.70	gold quality
body of uterus	UBERON:0009853	55.06	gold quality
omental fat pad	UBERON:0010414	54.91	gold quality
tibial nerve	UBERON:0001323	54.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Triptolide treatment sensitized the effect of cisplatin in A2780/CP70, as evidenced by decreased survival fraction of A2780/CP70 cells. microRNA 6751 expression level was upregulated in A2780/CP70 cells after triptolide treatment. (PMID:29966441)
• Cisplatin resistance and malignant behaviors of lung cancer cells are promoted by circ_0002360 via targeting miR-6751-3p to regulate the expression of ZNF300. (PMID:35166026)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.