MIR6752

Summary

MIR6752 (microRNA 6752, HGNC:50020) is a microRNA gene on chromosome 11q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465450 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50020
Approved symbol	MIR6752
Name	microRNA 6752
Location	11q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6752
Ensembl gene	ENSG00000276769
Ensembl biotype	miRNA
Entrez	102465450
RNAcentral	URS000075BBC3 — miRNA, 71 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000618442

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618442 — 1 exons

Exon	Start	End
ENSE00003735119	67490245	67490315

Expression profiles

Bgee: expression breadth broad, 79 present calls, max score 78.85.

Top tissues by expression

79 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	78.85	gold quality
muscle of leg	UBERON:0001383	77.33	gold quality
blood	UBERON:0000178	74.75	gold quality
monocyte	CL:0000576	74.74	gold quality
islet of Langerhans	UBERON:0000006	73.33	gold quality
gastrocnemius	UBERON:0001388	72.87	gold quality
lymph node	UBERON:0000029	72.83	gold quality
prefrontal cortex	UBERON:0000451	71.06	gold quality
body of pancreas	UBERON:0001150	70.67	gold quality
tonsil	UBERON:0002372	70.65	gold quality
body of stomach	UBERON:0001161	69.68	gold quality
heart left ventricle	UBERON:0002084	69.36	gold quality
right lobe of liver	UBERON:0001114	68.65	gold quality
Ammon’s horn	UBERON:0001954	67.98	gold quality
rectum	UBERON:0001052	67.59	gold quality
adult mammalian kidney	UBERON:0000082	67.27	gold quality
right atrium auricular region	UBERON:0006631	67.15	gold quality
endometrium	UBERON:0001295	66.78	gold quality
ascending aorta	UBERON:0001496	66.61	gold quality
thoracic aorta	UBERON:0001515	66.54	gold quality
colon	UBERON:0001155	66.26	gold quality
granulocyte	CL:0000094	66.19	gold quality
transverse colon	UBERON:0001157	66.02	gold quality
left adrenal gland cortex	UBERON:0035825	65.89	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.86	gold quality
tibial artery	UBERON:0007610	65.76	gold quality
esophagus mucosa	UBERON:0002469	65.73	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.71	gold quality
endocervix	UBERON:0000458	65.70	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.10

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.